Jakość życia pacjentów po rekonstrukcji więzadła krzyżowego przedniego z zastosowaniem przeszczepu syntetycznego LARS i przeszczepu autogennego ST/GR

Introduction

In recent years, injuries to the anterior cruciate ligament (ACL) have become a real epidemic. The injury most often concerns young, physically active individuals aged 15–25 years [1]. As many as 70% of ACL injuries are non-contact injuries, which most frequently occur during a sudden change of running direction or landing after a jump [2, 3]. The consequence of damage to the ligamentous apparatus of the knee joint is its instability. It causes disorders of the functional capability of the limb, both in daily life and during attempts to return to full physical activity, and in the later period it contributes to the development of degenerative disease [4]. Instability of the knee joint requires surgical treatment. For many years, arthroscopy has been the method of choice applied for treatment of ruptures of the ACL [5]. The material most often used for the reconstruction of the anterior cruciate ligament are autologous tendons of the semitendinous or gracilis muscle. Synthetic materials are considerably more rarely applied for ACL reconstruction, although their use has been described since the 1970s [6]. At present, in some orthopaedic wards in Poland, ACL reconstructions are performed using the LARS synthetic ligament. Due to the mechanical and structural characteristics of the ligament, this method allows considerable acceleration of the return to normal function of the knee joint and, consequently, the return to physical and occupational activity [7].
It is commonly known that the disease, to varying degrees, disturbs the functioning of people, thus having an effect on quality of life in many dimensions and in various periods of time. Since the 1990s, the concept of quality of life has been associated primarily with the state of health. However, many researchers considered that quality of life is not only a state of health, but also of social position or social situation [8]. In the case of injuries to the ACL and evaluation of the quality of life of patients within 4 years of surgery, it seems that the quality of life may be assessed according to one of the sociologic definitions, which states that ‘the quality of life covers those needs of an individual that are considered by this individual as most important for their own life, and an individual’s opinions concerning the level of satisfaction of these needs’ [9]. The goal of each patient who has undergone the reconstruction of damaged ACL is the return to the activity from before the injury [10]. If, and in what dimension this is successful, may affect the evaluation of the quality of life of the individual. Correctly planned rehabilitation is an indispensable element of treatment of patients after ACL reconstruction [11]. It is aimed at the restoration of the lost function of the knee joint, and consequently, improvement of the quality of life of patients.

Aim of the research

The objective of the study was the determination of the level of quality of life of patients after ACL reconstruction using the LARS synthetic ligament or autogenous ST/GR graft within 4 years after the surgery.

Material and methods

Into the study were qualified 96 patients, in whom, during the period 2010–2012, reconstruction was performed in the Holy Family Specialist Hospital in Rudna Mała near Rzeszow, due to injury to the anterior cruciate ligament. The mean period between the reconstruction of the ligament and the examination was 4 years.
From the study were excluded patients aged over 50 years, those who had undergone the reconstruction of more than one ligament, with a currently present injury in one of the joints in the healthy or operated limb, and patients in whom revision reconstruction had been performed.
As a criterion neutral for the study were considered concomitant surgeries of suturing, or removal of the fragments of the meniscus performed during the primary ACL reconstruction.
The patients were divided into two groups according to the type of material used for the reconstruction. The study group consisted of 44 (45.8%) patients operated on with the use of the LARS synthetic ligament. The control group included 52 (54.2%) patients who had been transplanted with an autogenous graft from the semitendinous or gracilis muscle.
In the study, the results were analysed of patients aged 27–50 years. The patients who had undergone an autogenous graft were approximately 4 years younger, on average (x– = 34.6; Me = 33.5; SD = 7.3), than those operated on using the LARS method (x– = 38.8; Me = 39.0; SD = 8.0).
In the population examined, the number of males was considerably higher than that of females – 76 and 20, respectively. The selection of such a group depended on a limited number of patients who had undergone surgery using the LARS method. Both groups were comparable with respect to gender. In the LARS group, there were 37 (84.1%) males, and 7 (15.9%) females, whereas in the group with autogenous graft there were 39 (75.0%) males and 13 (25.0%) females.
The presented study was conducted by means of a diagnostic survey, and the research instrument was the SF36v2 questionnaire for assessment of quality of life. The questionnaire contains 36 items grouped into eight domains: physical functioning, social functioning, role limitations due to physical health; role limitations due to emotional problems, mental health, vitality, bodily pain, and general health perceptions. In each domain, the possible result was within the range 0 – 100; the lower the number of scores, the worse the quality of life.

Statistical analysis

Statistical analyses were performed using descriptive statistics and Mann-Whitney U test. A p-value < 0.05 was considered statistically significant.

Results

Based on information collected by means of the SF-36v2 questionnaire, the quality of life of patients after surgery was assessed. Table 1 presents descriptive statistics, characterising the distribution of quality of life measures in the total population examined.
The patients expressed the most negative evaluations in the domain of General Health (GH) (x– = 62.5 scores) and perception of Mental Health (MH) (x– = 70.4 scores). The most positive evaluations concerned the domain of role limitations due to physical health (Role Physical – RP) and role limitations due to emotional problems (Role Emotional – RE) (x– > 95 scores) (Table 1).
The quality of life of patients was compared according to the type of surgery performed. No statistically significant differences were observed in the level of measurements of the quality of life. The assessment of the quality of life in the area of social functioning and mental health were slightly higher in the group of patients who were operated on using the LARS method. The differences were close to statistically significant (the value of the test probability p was lower than 0.10) (Table 2).
The type of rehabilitation undertaken in patients who had undergone ACL reconstruction using the semitendinosus–gracilis autograft (ST–GR) was significant for the evaluation of the quality of life. Patients who, apart from physical procedures, had undergone procedures within the scope of kinesiotherapy obtained significantly higher results in the assessment of the quality of life with respect to the domain of physical functioning, perception of general health, as well as the summary index of physical health (Table 3).
In the group of patients who had undergone surgery using the LARS method, it was observed that the type of rehabilitation did not determine the result of the study in any of the domains of the quality of life within the period of 4 years after surgery (Table 4).

Discussion

In the literature there are few reports concerning the quality of life of patients who had undergone reconstruction of ACL rupture. Barenius et al., during an 8-year period of observation of patients after autogenous graft, presented the mean result in the SF-36 scale of 75 scores (the respondents obtained the lowest result with respect to the domain of vitality – 67 scores). The researchers considered that the accompanying damage to the meniscus results in a more negative assessment of the quality of life in patients in whom the reconstruction of ACL rupture was performed [12]. These results are similar to the results of our own study (mean result – 83.1 scores), despite a considerable difference in time when they were performed. Busija et al., in a study conducted 2 years after the reconstruction of ACL using ST/GR graft, presented the results obtained by means of the SF-36 questionnaire with a mean level of 83.4 scores. This result is nearly identical to that obtained in the presented study. According to the above-mentioned researchers, the patients expressed the most negative evaluations with respect to their own vitality – on the level of 71 scores, and pain – 75.2 scores [13].
Månsson et al., using the SF-36 questionnaire, examined 78 patients in Sweden, 2–7 years after reconstruction using the ST/GR graft. Compared to the Swedish patients operated on using the ST/GR graft, patients from Poland function worse in the domain of perception of mental health (MH (x– = 68.2 vs. 82.2), in the sphere of social functioning (SF x– = 87.0 vs. 91.9), and general health (GH (x– = 63.0 vs. 82.2). In the remaining domains of quality of life the patients in our own study obtained better results. In addition, Swedish researchers compared the results obtained using the SF-36 questionnaire from patients who had undergone surgery using the ST/GR graft, and those operated on using the patellar tendon graft – 331 patients. They did not find any differences between groups in any of the domains [14]. Gao et al., while conducting a study in China among 156 patients, showed that 127 of them (81%) had a feeling of full satisfaction with life after surgery performed using the LARS method, while only 4 (3%) patients were very dissatisfied [15]. Falconer et al. assessed the quality of life of patients 2 years after the ACL reconstruction with the double-bundle technique – ST/GR graft – control group (27 patients), and using the double-bundle technique – ST/GR graft and LARS ligament – LARS group (61 patients). The quality of life was investigated by means of the ACL-QOL questionnaire, and no significant differences were found between groups: (x– = 80.00 (control group) and x– = 80.16 (LARS group)) [16]. Núńez et al. compared the quality of life of patients 2 years after ACL reconstruction with the single-bundle technique (23 patients) and using the double-bundle technique (29 patients). The results obtained are comparable; however, the double-bundle technique is more expensive [17]. In the presented study, the quality of life of patients was compared according to the type of graft – autogenous ST/GR graft vs. LARS synthetic ligament. No statistically significant differences were observed in the level of patients’ quality of life. However, the assessment in the domain of social functioning and mental health was slightly higher, and the values were close to the threshold of statistical significance in the group of patients who had undergone surgery using the LARS method. At the same time, this method is more costly than autogenous graft.
Machotka et al. performed a review of literature concerning the results obtained after ACL reconstruction using the LARS method. From among 20 articles published during 2000–2010 in eight databases, only four satisfied the criteria of enrolment into the analysis. A high level of patient satisfaction with life after the surgery was the only consistent result published in the analysed studies. However, the conclusion drawn from literature review is alarming because there is a lack of verified standards for conducting thorough rehabilitation of patients with the LARS ligament [18]. A study carried out by Jarosz et al., based on the results obtained from 201 patients after the ACL reconstruction with autogenous graft, and who received rehabilitation within the period of 6 months after the surgery, found that an improvement in the mental, physical, and social sphere of quality of life depended on the improvement of the results of orthopaedic examination concerning stability and the range of mobility in the knee joint [19]. In the presented study, the patients who had undergone ACL using ST/GR graft and subsequently received complex rehabilitation, including both individually adjusted kinesiotherapy as well as physiotherapy, obtained significantly better results in the domains of physical functioning, perception of general health, and summary index of physical health. Nevertheless, no differences were observed in the perceived quality of life in patients in the LARS group, according to the type of rehabilitation applied.
Assessment of quality of life should constitute an integral element of evaluation of the state of health of patients after ACL reconstruction, irrespective of the type of graft and method applied. Analysis of the effect of injury and reconstruction surgery on individual domains of life may help to establish the direction of therapeutic management. The present socio-economic situation and constantly growing health need of society indicate an improvement of the quality of life as the basic dimension of the effectiveness of therapy.

Conclusions

The quality of life of patients within four years after ACL reconstruction surgery using the LARS method and autogenous graft is on a similar, high level. The application of complex rehabilitation in the form of the method of kinesiotherapy combined with physiotherapeutic procedures results in an improvement of the quality of life of patients treated using the autogenous graft. In patients in whom the LARS was applied, no differences in the evaluations of the quality of life were observed according to the type of rehabilitation undertaken.

Conflict of interest

The authors declare no conflict of interest.

References

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Address for correspondence:

Jędrzej Płocki
Department of Rehabilitation
Holy Family Specialist Hospital
Rudna Mała 600, 36-060 Głogów Młp., Poland
Phone: +48 781 529 464
E-mail: jplocki@gazeta.pl