eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2020
vol. 45
 
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abstract:
Clinical immunology

Joint remodeling outcome of serum levels of Dickkopf-1 (DKK1), cartilage oligomeric matrix protein (COMP), and C-telopeptide of type II collagen (CTXII) in rheumatoid arthritis

Naglaa K. Idriss
1
,
Rania M. Gamal
2
,
Marwa A. Gaber
1
,
Eman H. El-Hakeim
2
,
Nevin Hammam
2
,
Abeer M. Ghandour
2
,
Marwa Mahmoud Abdelaziz
2
,
Samar H. Goma
2

  1. Department of Medical Biochemistry, Assiut University, Assiut, Egypt
  2. Department of Rheumatology, Rehabilitation and Physical Medicine, Assiut University Hospital, Assiut, Egypt
(Centr Eur J Immunol 2020; 45 (1): 73-79)
DOI: https://doi.org/10.5114/ceji.2020.94685
Online publish date: 2020/04/06
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Introduction
Rheumatoid arthritis (RA) is the most widespread chronic inflammatory rheumatic disease over the world. It is characterized by chronic proliferation of synovium, cartilage destruction, and periarticular erosion/bone loss. We investigated the serum levels of the C-telopeptide of type II collagen (CTX-II), Dickkopf-1 (DKK1), and cartilage oligomeric matrix protein (COMP) in relationship to the disease activity.

Material and methods
Serum COMP, CTX-II, and DKK1 levels were measured in 63 RA patients and 50 person age and gender matched as a healthy controls by ELISA test. Disease activity score (DAS) were calculated.

Results
The mean level of and COMP and CTX-II were significantly higher in patients with RA than in healthy controls (5.71 ±7.04 vs. 2.70 ±1.31 ng/ml, and 0.45 ±0.27 vs. 0.23 ±0.16 ng/ml, respectively; p < 0.001). Also, DKK1 serum levels were significantly higher in patients with RA than in healthy controls (6970.68 ±7566.68 vs. 3276.96 ±1306.77 pg/m; p < 0.001). There was a positive significant correlation between DKK1 and swollen joint (r = 0.42, p < 0.001). There were no significant differences in the number of patients, gender, the duration of RA disease, DAS, and RF. Sensitivity was 58.7% and specificity was 85.7% at a cut-off point (> 3.6 ng/ml) for serum COMP in RA patients, while, sensitivity was 100% and specificity was 52.4% at a cut-off point (> 0.15 ng/ml) for serum CTX-II and sensitivity was 68.3% and specificity was 95.2 % at a cut-off point (> 4876 pg/ml) for serum DKK1.

Conclusions
Measurement of some serological biomarkers such as CTX-II, COMP, and DKK1 that reflect bone and cartilage destruction in RA patients could be used to indicate disease activity and early joint affection.

keywords:

rheumatoid arthritis (RA), C-telopeptide of type II collagen (CTX-II), Dickkopf-1 (DKK1), cartilage oligomeric matrix protein (COMP), disease activity
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