Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma

Piotr Czapiewski; Maciej Bobowicz; Rafał Pęksa; Marcin Skrzypski; Adam Gorczyński; Kamila Szczepańska-Michalska; Aleksandra Korwat; Michał Jankowski; Wojciech Zegarski; Anna Szulgo-Paczkowska; Tomasz Polec; Michał Piątek; Jarosław Skokowski; Johannes Haybaeck; Anna Żaczek; Wojciech Biernat

doi:10.5114/pjp.2016.63774

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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3/2016
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abstract:

Original paper

Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma

Piotr Czapiewski

^{1, 2}

,

Maciej Bobowicz

³

,

Rafał Pęksa

¹

,

Marcin Skrzypski

⁴

,

Adam Gorczyński

¹

,

Kamila Szczepańska-Michalska

⁵

,

Aleksandra Korwat

⁵

,

Michał Jankowski

⁶

,

Wojciech Zegarski

⁶

,

Anna Szulgo-Paczkowska

⁷

,

Tomasz Polec

³

,

Michał Piątek

⁸

,

Jarosław Skokowski

³

,

Johannes Haybaeck

^{2, 9}

,

Anna Żaczek

¹⁰

,

Wojciech Biernat

¹

Department of Pathomorphology, Medical University of Gdańsk, Gdańsk, Poland
Department of Pathology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany
Department of Oncological Surgery, Medical University of Gdańsk, Gdańsk, Poland
Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland
Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland
Chair of Oncological Surgery, Collegium Medicum, Nicolaus Copernicus University; Oncology Centre, Bydgoszcz, Poland
Department of Clinical Oncology, Centre of Oncology, Bydgoszcz, Poland
Department of Clinical Oncology of the University Clinical Centre, Silesian Medical University, Katowice, Poland
Department of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria
Department of Medical Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland

Pol J Pathol 2016; 67 (3): 228-234

DOI: https://doi.org/10.5114/pjp.2016.63774

Online publish date: 2016/11/25

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AMA

Czapiewski P, Bobowicz M, Pęksa R, et al. Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma. Polish Journal of Pathology. 2016;67(3):228-234. doi:10.5114/pjp.2016.63774.

APA

Czapiewski, P., Bobowicz, M., Pęksa, R., Skrzypski, M., Gorczyński, A.,  & Szczepańska-Michalska, K. et al. (2016). Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma. Polish Journal of Pathology, 67(3), 228-234. https://doi.org/10.5114/pjp.2016.63774

Chicago

Czapiewski, Piotr, Maciej Bobowicz, Rafał Pęksa, Marcin Skrzypski, Adam Gorczyński, Kamila Szczepańska-Michalska,  and Aleksandra Korwat et al. 2016. "Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma". Polish Journal of Pathology 67 (3): 228-234. doi:10.5114/pjp.2016.63774.

Harvard

Czapiewski, P., Bobowicz, M., Pęksa, R., Skrzypski, M., Gorczyński, A., Szczepańska-Michalska, K., Korwat, A., Jankowski, M., Zegarski, W., Szulgo-Paczkowska, A., Polec, T., Piątek, M., Skokowski, J., Haybaeck, J., Żaczek, A.,  and Biernat, W. (2016). Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma. Polish Journal of Pathology, 67(3), pp.228-234. https://doi.org/10.5114/pjp.2016.63774

MLA

Czapiewski, Piotr et al. "Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma." Polish Journal of Pathology, vol. 67, no. 3, 2016, pp. 228-234. doi:10.5114/pjp.2016.63774.

Vancouver

Czapiewski P, Bobowicz M, Pęksa R, Skrzypski M, Gorczyński A, Szczepańska-Michalska K et al. Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma. Polish Journal of Pathology. 2016;67(3):228-234. doi:10.5114/pjp.2016.63774.

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Colorectal carcinoma (CRC) is one of the leading causes of cancer-related deaths worldwide. Alterations in keratin expression, including keratin 7 (K7), are frequent findings in multiple cancers, and they constitute a prognostic factor. The aim of our study was to evaluate the prognostic significance of K7 in the primary tumour and lymph node metastases in two separate cohorts of patients: the first one with lymph node involvement (LN+, 129 cases) and the second one free of LN metastases (LN–, 85 cases).

Keratin 7 expression in CRC was analysed on tissue microarrays with immunohistochemistry and evaluated using the h-score. In the LN+ group K7 positivity was identified in 7/129 (5.4%) of primary tumours (PT) and lymph node metastases (LNM); concordance between them was 94% ( 0.396). Keratin 7 was expressed in 8/85 cases (9.4%) in the LN– group.

K7 expression in LNM of the LN+ cohort correlated with shorter overall survival (OS) (p = 0.047) and presence of distant metastases at diagnosis (p = 0.005). Expression of K7 in the primary tumour in both cohorts did not correlate with survival.

We conclude that the status of K7 expression in metastatic lymph nodes from CRC is a poor prognostic factor.

keywords:

Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma

keratin 7, metastasis, colon carcinoma, prognosis, lymph node metastases