eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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3/2021
vol. 72
 
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abstract:
Original paper

L1 cell adhesion molecule (L1CAM) and nerve growth factor receptor (NGFR, p75) expression patterns in solid pseudopapillary neoplasm of the pancreas

Łukasz Liszka
1

  1. Department of Pathomorphology and Molecular Diagnostics, Medical University of Silesia, Katowice, Poland
Pol J Pathol 2021; 72 (3): 211-221
Online publish date: 2022/01/19
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Solid pseudopapillary neoplasm (SPN) is a pancreatic tumor, which should be distinguished from neuroendocrine tumors (NET). It was postulated that SPN arise from the neural crest (NC). The purpose of the study was to examine expression levels of NC markers: L1 cell adhesion molecule (L1CAM) and nerve growth factor receptor (NGFR) in SPN and NET using immunohistochemistry (IHC) and tissue microarrays, aiming to test their potential utility as auxiliary IHC markers for differential diagnosis of SPN vs. NET. In the training cohort (n = 16 SPN), all cases showed L1CAM expression (usually weak, median extent 45% of cells), and NGFR expression (usually moderate to strong, median extent 100% of cells). In the validation cohort (n = 10 SPN), 90% of cases were L1CAM-positive (usually weak expression, median extent 15% of cells), and 100% were NGFR-positive (usually weak expression, median extent 70% of cells). Among NET cases (n = 29) L1CAM was found in 2 (7%), and NGFR in 1 case (3%). L1CAM and NGFR were expressed in SPN, but the intensities and extent of IHC staining differed across the cases. L1CAM and NGFR expression was rare in NET. Both markers may be further tested for their diagnostic utility for SPN vs. NET differential diagnosis. L1CAM/NGFR expression supports NC origin/differentiation of SPN.
keywords:

pancreas, pancreatic neoplasms, neural cell adhesion molecule L1, nerve growth factor receptor

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