Lack of association between COX-2 8473T>C polymorphism and breast cancer risk: a meta-analysis

Jun Jiang; Xun-Feng Quan; Li Zhang; Li Shen; Ming-Xia Zhang; Hui-hui Ma; Yi-Chun Wang

doi:10.5114/wo.2014.41394

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2014
vol. 18

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abstract:

Original paper

Lack of association between COX-2 8473T>C polymorphism and breast cancer risk: a meta-analysis

Jun Jiang

,

Xun-Feng Quan

,

Li Zhang

,

Li Shen

,

Ming-Xia Zhang

,

Hui-hui Ma

,

Yi-Chun Wang

Contemp Oncol (Pozn) 2014; 18 (3): 177–181

DOI: https://doi.org/10.5114/wo.2014.41394

Online publish date: 2014/06/18

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Aim of the study: Results of recent published studies on the association between the COX-2 8473T>C polymorphism and the risk of breast cancer have often been conflicting. To make a more precise estimation of the potential relationship, a meta-analysis was performed.

Material and methods: A total of seven case-control studies with 7,033 cases and 9,350 controls were included in the current meta-analysis through searching the databases of PubMed, Embase, and Cochrane Library (up to March 1st, 2013). The odds ratio (OR) and 95% confidence interval (95% CI) were calculated to assess the strength of the association. The meta-analysis was conducted in a fixed/random effect model.

Results: We found no significant associations for all genetic models after all studies were pooled into the meta-analysis (for C vs. T: OR = 0.974, 95% CI: 0.906–1.047, p = 0.471; for CC vs. TT: OR = 0.957, 95% CI: 0.803–1.140, p = 0.62; for TC vs. TT: OR = 0.964, 95% CI: 0.881–1.055, p = 0.421; for CC + TC vs. TT: OR = 0.963, 95% CI: 0.880–1.053, p = 0.406; for CC vs. TT + TC: OR = 0.978, 95% CI: 0.831–1.15, p = 0.788). We also observed no obvious associations in the subgroup analyses by ethnicity (Caucasian) and source of controls (population based, PB) for all genetic models.

Conclusions: Current evidence suggests that the COX-2 8473T>C polymorphism is not associated with breast cancer risk.

keywords:

Lack of association between COX-2 8473T>C polymorphism and breast cancer risk: a meta-analysis

Jun Jiang , Xun-Feng Quan , Li Zhang , Li Shen , Ming-Xia Zhang , Hui-hui Ma , Yi-Chun Wang

breast cancer, polymorphism, meta-analysis, COX-2

Jun Jiang

,

Xun-Feng Quan

,

Li Zhang

,

Li Shen

,

Ming-Xia Zhang

,

Hui-hui Ma

,

Yi-Chun Wang