Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment

Michalina Jezierska; Joanna Stefanowicz; Grzegorz Romanowicz; Wojciech Kosiak; Magdalena Lange

doi:10.5114/pdia.2017.67095

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2018
vol. 35

Send email

Copy url:

abstract:

Review paper

Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment

Michalina Jezierska

,

Joanna Stefanowicz

,

Grzegorz Romanowicz

,

Wojciech Kosiak

,

Magdalena Lange

Adv Dermatol Allergol 2018; XXXV (1): 6-17

DOI: https://doi.org/10.5114/pdia.2017.67095

Online publish date: 2018/02/20

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M. Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2018;35(1):6-17. doi:10.5114/pdia.2017.67095.

APA

Jezierska, M., Stefanowicz, J., Romanowicz, G., Kosiak, W.,  & Lange, M. (2018). Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 35(1), 6-17. https://doi.org/10.5114/pdia.2017.67095

Chicago

Jezierska, Michalina, Joanna Stefanowicz, Grzegorz Romanowicz, Wojciech Kosiak,  and Magdalena Lange. 2018. "Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 35 (1): 6-17. doi:10.5114/pdia.2017.67095.

Harvard

Jezierska, M., Stefanowicz, J., Romanowicz, G., Kosiak, W.,  and Lange, M. (2018). Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 35(1), pp.6-17. https://doi.org/10.5114/pdia.2017.67095

MLA

Jezierska, Michalina et al. "Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 35, no. 1, 2018, pp. 6-17. doi:10.5114/pdia.2017.67095.

Vancouver

Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M. Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2018;35(1):6-17. doi:10.5114/pdia.2017.67095.

Langerhans cell histiocytosis is a rare clonal disease characterized by the proliferation of CD1a-positive immature dendritic cells. The purpose of this article was to present an updated review of recent advances in the pathogenesis, clinical features, imaging and treatment of this disease. The discovery of oncogenic BRAF mutations and the presence of proinflammatory cytokines and chemokines confirmed the unusual characteristics of this disease. Currently, children with organ involvement who do not have a good response to chemotherapy and have neurodegeneration or diabetes insipidus are the most problematic patients. Further research is needed to improve the results of treatment.

keywords:

Langerhans cell histiocytosis in children – a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment

Michalina Jezierska , Joanna Stefanowicz , Grzegorz Romanowicz , Wojciech Kosiak , Magdalena Lange

Langerhans cell histiocytosis, children, pathogenesis, symptoms, treatment

Michalina Jezierska

,

Joanna Stefanowicz

,

Grzegorz Romanowicz

,

Wojciech Kosiak

,

Magdalena Lange