Langerhans cell histiocytosis of the atlas in a female adult

Langerhans cell histiocytosis (LCH) is an infrequent disorder complex. It is a disease of myeloid dendritic cells, lymphocytes, and macrophages mixed with eosinophils and neutrophils [1]. The accumulation of these cells causes the classic lytic bone lesions, skin rashes, lymphadenopathy, and organ dysfunction. Langerhaus cell histocytosis occurs at all ages from infancy up to senility with the peak incidence between 2 and 4 years of age. The male/female ratio is about 3.7 : 1 [2]. We have recently treated a case of LCH of the atlas in a female adult, which may be the first case of atlas LCH in a female adult reported in the English literature. A 26-year-old woman complained of headache for 10 years, with aggravation for 3 months. No neurological deficits were observed, and no significant medical history or family history was reported. Physical examination demonstrated obvious restriction of the neck motion without neurological deficit or torticollis.
Computed tomography (CT) examination confirmed a sharply osteolytic lesion of the right posterior lacerate foramen area. The atlas right lateral mass, anterior arch and squamous part of occipital bone had been eroded with attenuation. The gap between the atlas and dentate was enlarged. The tumor mass had a similar density as soft tissue such as muscles in a plain CT scan; however, after enhancement, the tumor mass density overall increased obviously, but not very uniformly. On magnetic resonsnce imaging MRI, the soft tissue mass was isointense on T1, but it enhanced homogeneously after contrast administration (Fig. 1A–D). The patient underwent surgical treatment. Under general anesthesia a grey-red tumor of approximately 3.5 × 5.5 × 6 cm was completely removed from the atlas. The tumor had a tough texture with clear border and abundant blood supply.
Histopathologically, it was proven to be LCH. At higher magnification, the proliferating cells had indented and folded or grooved nuclei resembling coffee beans. Multinuclear giant cells were frequently seen. Eosinophils and neutrophils were admixed with the proliferating cells. The main cells were positive for S-100 protein (Fig. 1E and F).
Skull and mandible are common regions of LCH involvement, and there have been very few published cases describing Langerhans cell histiocytosis of the atlas. On radiological examination, sharply demarcated punch-out osteolytic lesions in bones are characteristic. Final LCH diagnosis is possible based only...


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