Large cell acanthoma – clinical and nosological controversies

Joanna Wojtania; Wojciech Biernat; Anna Woźniacka

doi:10.5114/dr.2024.142719

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2024
vol. 111

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abstract:

Case report

Large cell acanthoma – clinical and nosological controversies

Joanna Wojtania

¹

,

Wojciech Biernat

²

,

Anna Woźniacka

¹

Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland

Dermatol Rev/Przegl Dermatol 2024, 111, 140-143

DOI: https://doi.org/10.5114/dr.2024.142719

Online publish date: 2024/09/13

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Introduction:
Large cell acanthoma is a rare, benign epidermal neoplasm of unknown aetiology. Because of the ongoing nosological debate, some authors regard it as a separate independent entity, while others classify it as a subtype of other conditions like lentigo, seborrheic keratosis, actinic keratosis, or even Bowen’s disease. Large cell acanthomas are usually solitary lesions located within sun-exposed skin, well-demarcated from surrounding. The diagnosis is always based on histological examination.

Objective:
Presentation of the characteristic clinical, videodermatoscopic, and histopathological features of this rare neoplasm.

Case report:
The paper presents the case of a 76-year-old man who, for several years, had been observing a gradually spreading, yellow-brown lesion with a hyperkeratotic surface, located on the skin of his upper back. Based on histological examination, large cell acanthoma was diagnosed.

Conclusions:
Histological examination plays a crucial role in the differential diagnosis of atypical skin lesions, including large cell acanthoma.

keywords:

Large cell acanthoma – clinical and nosological controversies

Joanna Wojtania 1 , Wojciech Biernat 2 , Anna Woźniacka 1

large cell acanthoma, dermatoscopy, solar lentigo, actinic keratosis

Joanna Wojtania

¹

,

Wojciech Biernat

²

,

Anna Woźniacka

¹