Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients

Yermek Turgunov; Alina Ogizbayeva; Lyudmila Akhmaltdinova; Kayrat Shakeyev

doi:10.5114/wo.2021.110051

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

3/2021
vol. 25

Send email

Copy url:

abstract:

Original paper

Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients

Yermek Turgunov

¹

,

Alina Ogizbayeva

¹

,

Lyudmila Akhmaltdinova

²

,

Kayrat Shakeyev

¹

Department of Surgical Diseases, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan
Collective Use Laboratory of the Research Center, NJSC “Karaganda Medical University”, Karaganda, Kazakhstan

Contemp Oncol (Pozn) 2021; 25 (3): 198–203

DOI: https://doi.org/10.5114/wo.2021.110051

Online publish date: 2021/10/14

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Turgunov Y, Ogizbayeva A, Akhmaltdinova L, Shakeyev K. Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients. Contemporary Oncology/Współczesna Onkologia. 2021;25(3):198-203. doi:10.5114/wo.2021.110051.

APA

Turgunov, Y., Ogizbayeva, A., Akhmaltdinova, L.,  & Shakeyev, K. (2021). Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients. Contemporary Oncology/Współczesna Onkologia, 25(3), 198-203. https://doi.org/10.5114/wo.2021.110051

Chicago

Turgunov, Yermek, Alina Ogizbayeva, Lyudmila Akhmaltdinova,  and Kayrat Shakeyev. 2021. "Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients". Contemporary Oncology/Współczesna Onkologia 25 (3): 198-203. doi:10.5114/wo.2021.110051.

Harvard

Turgunov, Y., Ogizbayeva, A., Akhmaltdinova, L.,  and Shakeyev, K. (2021). Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients. Contemporary Oncology/Współczesna Onkologia, 25(3), pp.198-203. https://doi.org/10.5114/wo.2021.110051

MLA

Turgunov, Yermek et al. "Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients." Contemporary Oncology/Współczesna Onkologia, vol. 25, no. 3, 2021, pp. 198-203. doi:10.5114/wo.2021.110051.

Vancouver

Turgunov Y, Ogizbayeva A, Akhmaltdinova L, Shakeyev K. Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients. Contemporary Oncology/Współczesna Onkologia. 2021;25(3):198-203. doi:10.5114/wo.2021.110051.

PlumX metrics:

Introduction
In this pilot study lipopolysaccharide-binding protein (LBP) levels were assessed as a possible risk factor for development of systemic inflammatory response syndrome (SIRS) and infectious and inflammatory complications in colorectal cancer (CRC) patients after surgery.

Material and methods
For LBP determination venous blood was taken 1 hour before the surgery and 72 hours after it. All patients were stratified by the presence or absence of acute bowel obstruction (ABO), SIRS and complications.

Results
36 patients with CRC participated in the study. The LBP level before surgery was 879.8 ± 221.8 ng/ml (interquartile range (IQR) 749.3–1028.8); on the 3rd day it was 766.5 ± 159.4 ng/ml (IQR 669.5–847.6), which was a statistically significant decrease (p = 0.004). A decrease in LBP level by more than 280 ng/ml increases the probability of SIRS and complications in operated CRC patients (OR 6.6, 95% CI: 1.1–40.9 and OR 12.0, 95% CI: 1.8–80.4, respectively). In patients with ABO in the presence of SIRS, the LBP value decreased more than in those without SIRS (p = 0.046).

Conclusions
This study demonstrated that the LBP level in the operated CRC patients tends to decrease on the 3rd day after surgery. A bigger decrease in LBP level increases the probability of SIRS and postoperative infectious and inflammatory complications. Therefore, further studies with larger numbers of patients are required.

keywords:

Lipopolysaccharide-binding protein as a risk factor for development of infectious and inflammatory postsurgical complications in colorectal cancer patients

Yermek Turgunov 1 , Alina Ogizbayeva 1 , Lyudmila Akhmaltdinova 2 , Kayrat Shakeyev 1

lipopolysaccharide-binding protein, colorectal cancer, bowel obstruction, bacterial translocation, SIRS, complications

Yermek Turgunov

¹

,

Alina Ogizbayeva

¹

,

Lyudmila Akhmaltdinova

²

,

Kayrat Shakeyev

¹