Lipoprotein lipase; a new prognostic factor in chronic lymphocytic leukemia

Mariusz L. Hartman; Zofia M. Kilianska

doi:10.5114/wo.2012.32476

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/2012
vol. 16

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abstract:

Review paper

Lipoprotein lipase; a new prognostic factor in chronic lymphocytic leukemia

Mariusz L. Hartman

,

Zofia M. Kilianska

Wspolczesna Onkol 2012; 16 (5): 474–479

DOI: https://doi.org/10.5114/wo.2012.32476

Online publish date: 2013/01/04

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The clinical course of patients with chronic lymphocytic leukemia (CLL) is highly heterogeneous. Gene expression analyses have revealed that leukemic cells with unmutated immunoglobulin heavy chain genes (IgV_H) differ from CLL cells with mutated IgV_H in the expression level of some genes, i.e. encoding kinase ZAP-70 and antigen CD38. Recently, additional markers in CLL, including the expression level of apoptosis-regulating genes/proteins (Bcl-2, Mcl-1) and microRNAs, have been suggested. In this review, we attempt to provide data concerning the properties of lipoprotein lipase (LPL), as well as to present its prognostic value in CLL. LPL mRNA expression level was able to predict mutational status in a high percentage of CLL cases and high LPL expression was associated with shorter treatment-free survival. Importantly, since LPL activity is low (or absent) in other blood cell types, its expression can be determined by PCR technique in peripheral blood mononuclear cells or in lysed blood samples.

keywords:

Lipoprotein lipase; a new prognostic factor in chronic lymphocytic leukemia

Mariusz L. Hartman , Zofia M. Kilianska

chronic lymphocytic leukemia, prognostic factors, lipoprotein lipase, IgVH mutational status

Mariusz L. Hartman

,

Zofia M. Kilianska