Liver function test abnormalities in COVID-19 patients and factors affecting them – a retrospective study

Mona Mohammed Abdelrahman; Asmaa A. Abdel-baset; Mustafa Adel Younis; Mahmoud Gaber Mahmoud; Noha Saber Shafik

doi:10.5114/ceh.2021.109225

eISSN: 2449-8238
ISSN: 2392-1099

Clinical and Experimental Hepatology

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abstract:

Original paper

Liver function test abnormalities in COVID-19 patients and factors affecting them – a retrospective study

Mona Mohammed Abdelrahman

¹

,

Asmaa A. Abdel-baset

²

,

Mustafa Adel Younis

³

,

Mahmoud Gaber Mahmoud

²

,

Noha Saber Shafik

⁴

Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Egypt
Internal Medicine Department, Faculty of Medicine, Sohag University, Egypt
Clinical and Chemical Pathology Department, Faculty of Medicine, Sohag University, Egypt
Medical Microbiology and Immunology Department, Faculty of Medicine, Sohag University, Egypt

Clin Exp HEPATOL 2021; 7, 3: 297-304

DOI: https://doi.org/10.5114/ceh.2021.109225

Online publish date: 2021/09/23

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Introduction
We aimed to study liver function test abnormalities in our COVID-19 patients and factors affecting them and to evaluate whether liver function test abnormalities are related to the severity of COVID-19.

Material and methods
Our retrospective study included 118 patients who were SARS-CoV-2 positive. Their median age was 40 years. Fifty percent were male. Clinical and biochemical data were collected from patient records during the period from the start of June 2020 to the end of July 2020. Liver function test abnormalities included: alanine aminotransferase (ALT) > 40 U/l, aspartate aminotransferase (AST) > 40 U/l, serum albumin < 3.5 mg/dl, total bilirubin > 1.2 mg/dl, and international normalized ratio (INR) > 1.2.

Results
Forty-four percent of COVID-19 patients had liver function test (LFT) abnormalities. In patients with severe SARS-CoV-2, AST, total bilirubin and INR levels were significantly higher than in patients with the nonsevere disease. Levels of hemoglobin, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum ferritin, D-dimer, and serum glucose were significantly higher in SARS-CoV-2 patients with LFT abnormalities than those with normal liver function.

Conclusions
LFT abnormalities are very common in SARS-CoV2 positive patients, especially those with the severe form. Levels of ESR, CRP, serum ferritin, and D-dimer were higher in COVID-19 patients with LFT abnormalities than those with normal LFT. High serum ferritin levels might be potential risk factors for LFT abnormalities.

keywords:

Liver function test abnormalities in COVID-19 patients and factors affecting them – a retrospective study

Mona Mohammed Abdelrahman 1 , Asmaa A. Abdel-baset 2 , Mustafa Adel Younis 3 , Mahmoud Gaber Mahmoud 2 , Noha Saber Shafik 4

liver function tests, COVID-19, risk factors

Mona Mohammed Abdelrahman

¹

,

Asmaa A. Abdel-baset

²

,

Mustafa Adel Younis

³

,

Mahmoud Gaber Mahmoud

²

,

Noha Saber Shafik

⁴