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ISSN: 1426-3912
Central European Journal of Immunology
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3/2024
vol. 49
 
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Review paper

Long-term efficacy of mesenchymal stem cell treatment for complex perianal fistulas: A systematic review and meta-analysis

Tao Wang
1
,
Min Li
2
,
Hua Shang
2
,
Lei Zou
2
,
Feng Shang
3

  1. Department of Pediatric Surgery, Zibo Central Hospital, Zibo, Shandong, China
  2. Department of Gastroenterology, Zibo Central Hospital, Zibo, Shandong, China
  3. Department of Medical Security, The 908th Hospital of Chinese People’s Liberation Army Joint Logistic Support Force, China
Cent Eur J Immunol 2024; 49 (3): 273-281
Online publish date: 2024/11/12
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1. Zanotti C, Martinez-Puente C, Pascual I, et al. (2007): An assessment of the incidence of fistula-in-ano in four countries of the European Union. Int J Colorectal Dis 22: 1459-1462.
2. Sainio P (1984): Fistula-in-ano in a defined population. Incidence and epidemiological aspects. Ann Chir Gynaecol 73: 219-224.
3. Mahadev S, Young JM, Selby W, Solomon MJ (2011): Quality of life in perianal Crohn’s disease: what do patients consider important? Dis Colon Rectum 54: 579-585.
4. Cadeddu F, Salis F, Lisi G, et al. (2015): Complex anal fistula remains a challenge for colorectal surgeon. Int J Colorectal Dis 30: 595-603.
5. Peyrin-Biroulet L, Bouhnik Y, Roblin X, et al. (2017): French national consensus clinical guidelines for the management of Crohn’s disease. Dig Liver Dis 49: 368-377.
6. Lightner AL, Ashburn JH, Brar MS, et al. (2020): Fistulizing Crohn’s disease. Curr Probl Surg 57: 100808.
7. Panés J, Reinisch W, Rupniewska E, et al. (2018): Burden and outcomes for complex perianal fistulas in Crohn’s disease: Systematic review. World J Gastroenterol 24: 4821-4834.
8. Ardizzone S, Maconi G, Colombo E, et al. (2004): Perianal fistulae following infliximab treatment: clinical and endosonographic outcome. Inflamm Bowel Dis 10: 91-96.
9. DelaRosa O, Dalemans W, Lombardo E (2012): Mesenchymal stem cells as therapeutic agents of inflammatory and autoimmune diseases. Curr Opin Biotechnol 23: 978-983.
10. Garcia-Olmo D, Schwartz DA (2015): Cumulative evidence that mesenchymal stem cells promote healing of perianal fistulas of patients with Crohn’s disease – going from bench to bedside. Gastroenterology 149: 853-857.
11. Jones BJ, McTaggart SJ (2008): Immunosuppression by mesenchymal stromal cells: from culture to clinic. Exp Hematol 36: 733-741.
12. García-Olmo D, García-Arranz M, Herreros D, et al. (2005): A phase I clinical trial of the treatment of Crohn’s fistula by adipose mesenchymal stem cell transplantation. Dis Colon Rectum 48: 1416-1423.
13. Herreros MD, Garcia-Arranz M, Guadalajara H, et al. (2012): Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum 55: 762-772.
14. Garcia-Olmo D, Herreros D, Pascual I, et al. (2009): Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial. Dis Colon Rectum 52: 79-86.
15. Molendijk I, Bonsing BA, Roelofs, H, et al. (2015): Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn’s disease. Gastroenterology 149: 918-927.e6.
16. Panés J, García-Olmo D, Van Assche G, et al. (2016): Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet 388: 1281-1290.
17. Zhou C, Li M, Zhang Y, et al. (2020): Autologous adipose-derived stem cells for the treatment of Crohn’s fistula-in-ano: an open-label, controlled trial. Stem Cell Res Ther 11: 124.
18. Ascanelli S, Zamboni P, Campioni D, et al. (2021) Efficacy and Safety of treatment of complex idiopathic fistula-in-ano using autologous centrifuged adipose tissue containing progenitor cells: A randomized controlled trial. Dis Colon Rectum 64: 1276-1285.
19. Garcia-Olmo D, Gilaberte I, Binek, M, et al. (2022): Follow-up study to evaluate the Long-term safety and efficacy of darvadstrocel (Mesenchymal Stem Cell Treatment) in patients with perianal fistulizing Crohn’s Disease: ADMIRE-CD Phase 3 Randomized Controlled Trial. Dis Colon Rectum 65: 713-720.
20. Panés J, Bouma G, Ferrante M, et al. (2022): Inspect: A retrospective study to evaluate long-term effectiveness and safety of Darvadstrocel in patients with perianal fistulizing Crohn’s disease treated in the ADMIRE-CD trial. Inflamm Bowel Dis 28: 1737-1745.
21. Panés J, García-Olmo D, Van Assche G, et al. (2018): Long-term efficacy and safety of stem cell therapy (Cx601) for complex perianal fistulas in patients with Crohn’s disease. Gastroenterology 154: 1334-42.e1334.
22. Guadalajara H, Herreros D, De-La-Quintana P, et al. (2012): Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas. Int J Colorectal Dis 27: 595-600.
23. Cheng F, Huang Z, Li Z (2020): Efficacy and safety of mesenchymal stem cells in treatment of complex perianal fistulas: A meta-analysis. Stem Cells Int 2020: 8816737.
24. Choi S, Jeon BG, Chae G, Lee SJ (2019): The clinical efficacy of stem cell therapy for complex perianal fistulas: a meta- analysis. Tech Coloproctol 23: 411-427.
25. Cao Y, Su Q, Zhang B, et al. (2021): Efficacy of stem cells therapy for Crohn’s fistula: a meta-analysis and systematic review. Stem Cell Res Ther 12: 32.
26. Li A, Liu S, Li L, Yu M (2023): Mesenchymal stem cells versus placebo for perianal fistulizing Crohn’s disease: A systemic review and meta-analysis. Surg Innov 30: 398-405.
27. Amil-Dias J, Kolacek S, Turner D, et al. (2017): Surgical management of Crohn disease in children: Guidelines from the paediatric IBD Porto Group of ESPGHAN. J Pediatr Gastroenterol Nutr 64: 818-835.
28. Herman Y, Rinawi F, Rothschild B, et al. (2017): The characteristics and long-term outcomes of pediatric Crohn’s disease patients with perianal disease. Inflamm Bowel Dis 23: 1659-1665.
29. Brückner A, Werkstetter KJ, de Laffolie J, et al. (2018): Incidence and risk factors for perianal disease in pediatric Crohn disease patients followed in CEDATA-GPGE registry. J Pediatr Gastroenterol Nutr 66: 73-78.
30. Van Assche G, Dignass A, Reinisch W, et al. (2010): The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Special situations. J Crohns Colitis 4: 63-01.
31. Hinterleitner TA, Petritsch W, Aichbichler B, et al. (1997): Combination of cyclosporine, azathioprine and prednisolone for perianal fistulas in Crohn’s disease. Z Gastroenterol 35: 603-608.
32. Lennard-Jones JE (1983): Toward optimal use of corticosteroids in ulcerative colitis and Crohn’s disease. Gut 24: 177-181.
33. Sandborn WJ, Present DH, Isaacs KL, et al. (2003): Tacrolimus for the treatment of fistulas in patients with Crohn’s disease: a randomized, placebo-controlled trial. Gastroenterology 125: 380-388.
34. Ryan JM, Barry F, Murphy JM, Mahon BP (2007): Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. Clin Exp Immunol 149: 353-363.
35. Horton JA, Hudak KE, Chung EJ, et al. (2013): Mesenchymal stem cells inhibit cutaneous radiation-induced fibrosis by suppressing chronic inflammation. Stem Cells 31: 2231-2241.
36. Pezato R, de Almeida DC, Bezerra TF, et al. (2014): Immunoregulatory effects of bone marrow-derived mesenchymal stem cells in the nasal polyp microenvironment. Mediators Inflamm 2014: 583409.
37. English K (2013): Mechanisms of mesenchymal stromal cell immunomodulation. Immunol Cell Biol 91: 19-26.
38. Ivanova-Todorova E, Bochev I, Mourdjeva M, et al. (2009): Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells. Immunol Lett 126: 37-42.
Copyright: © 2024 Polish Society of Experimental and Clinical Immunology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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