Low frequency of skin cancers in vitiligo patients

Barbara Algiert; Anna Erkiert-Polguj; Agnieszka Dana; Dariusz Czubiński; Helena Rotsztejn

doi:10.5114/dr.2016.63840

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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6/2016
vol. 103

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abstract:

Review paper

Low frequency of skin cancers in vitiligo patients

Barbara Algiert

,

Anna Erkiert-Polguj

,

Agnieszka Dana

,

Dariusz Czubiński

,

Helena Rotsztejn

Przegl Dermatol 2016, 103, 486–490

DOI: https://doi.org/10.5114/dr.2016.63840

Online publish date: 2016/12/05

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Vitiligo is a disease characterized by discoloration of the skin and hair as a result of damage of melanocytes. The exact mechanism of the disease is still unknown. Theories about the pathogenesis focus on autoimmune, neurogenic and autocytotoxic mechanisms. There is a decreased risk of incidence of skin cancers in patients with vitiligo. The relation between vitiligo and decreased frequency of cases of malignant melanoma (MM) may be a consequence of the immune response to antigens, which are common for melanocytes and MM cells. Genetic studies indicate a mutually exclusive relationship of melanoma and vitiligo. This disease is also associated with a polymorphism in the TYR gene which encodes tyrosinase. Studies also indicate a decreased risk of incidence of nonmelanoma skin cancers (NMSC) in patients with vitiligo.

keywords:

Low frequency of skin cancers in vitiligo patients

Barbara Algiert , Anna Erkiert-Polguj , Agnieszka Dana , Dariusz Czubiński , Helena Rotsztejn

vitiligo, malignant melanoma, nonmelanoma skin cancers

Barbara Algiert

,

Anna Erkiert-Polguj

,

Agnieszka Dana

,

Dariusz Czubiński

,

Helena Rotsztejn