Low grade malignant peripheral nerve sheath tumor with mesenchymal differentiation: a case report

Karolina Janczar; Krzysztof Tybor; Mateusz Józefowicz; Wielisław Papierz

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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4/2011
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abstract:

Low grade malignant peripheral nerve sheath tumor with mesenchymal differentiation: a case report

Karolina Janczar

,

Krzysztof Tybor

,

Mateusz Józefowicz

,

Wielisław Papierz

POL J PATHOL 2011; 4: 278-281

Online publish date: 2012/01/10

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Malignant peripheral nerve sheath tumor (MPNST) is an uncommon neoplasm. Rarely, MPNST may display focal mesenchymal differentiation and this is more frequently encountered in high than low grade lesions. Here we present an example of a low grade MPNST with osteoid, cartilaginous and probably smooth muscle components occurring in the subtemporal fossa of a 26-year-old male patient with no associated neurofibromatosis type 1. The tumor exhibited diffuse S-100 protein expression, whereas immunostainings for epithelial membrane antigen and smooth muscle actin were positive in a portion of neoplastic cells.

keywords:

Low grade malignant peripheral nerve sheath tumor with mesenchymal differentiation: a case report

Karolina Janczar , Krzysztof Tybor , Mateusz Józefowicz , Wielisław Papierz

MPNST, mesenchymal differentiation

Karolina Janczar

,

Krzysztof Tybor

,

Mateusz Józefowicz

,

Wielisław Papierz