Lucilia sericata defensins and their capacity to stimulate wound regenerative processes. A review of the literature and our own observations

Dariusz Bazaliński; Mateusz Skórka; Paulina Szymańska; Anna Wójcik; Przemysław Lipiński

doi:10.5114/lr.2022.120200

eISSN: 1733-7607
ISSN: 1733-4101

Leczenie Ran

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3/2022
vol. 19

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abstract:

Review paper

Lucilia sericata defensins and their capacity to stimulate wound regenerative processes. A review of the literature and our own observations

Dariusz Bazaliński

^{1, 2}

,

Mateusz Skórka

³

,

Paulina Szymańska

⁴

,

Anna Wójcik

^{1, 2}

,

Przemysław Lipiński

⁵

Szpital Specjalistyczny, Podkarpacki Ośrodek Onkologii im. B. Markiewicza w Brzozowie
Instytut Nauk o Zdrowiu, Kolegium Nauk Medycznych, Uniwersytet Rzeszowski
Kliniczny Szpital nr 2 im. św. Jadwigi Królowej w Rzeszowie
Oddział Chirurgii Naczyniowej, Radomski Szpital Specjalistyczny, Radom
Pracownia Leczenia Ran, Centrum Medyczne ARGO, Łódź

LECZENIE RAN 2022; 19 (3): 94-105

DOI: https://doi.org/10.5114/lr.2022.120200

Online publish date: 2022/10/21

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Over the last decade the medical larvae of Lucilia sericata have been claimed to be “miracle therapeutic maggots” due to their manifold biochemical properties that stimulate healing processes in a wound. Isolating chemical substances from maggot excretions and secretions gives greater possibilities to develop research into the use of defensins to stimulate healing processes in wounds of different aetiologies. Current studies focus on isolation, identification, recombination, and production of selected substances.

A critical analysis of literature was done, based on studies published in the years 2000–2022. The authors conducted a review of scientific papers using the PubMed and Termedia databases using the following keywords: defensins, Lucilia sericata, maggot debridement therapy.

Lucilia sericata excretions/secretions have proven antibacterial, antibiofilm, anti-inflammatory, and synergistic properties with specific antibiotics effectiveness. Efforts should be made to increase the level of knowledge and engagement among clinicians to implement and recommend MDT not only for biodebridement, but also to stimulate regenerative processes in a wound.

keywords:

Lucilia sericata defensins and their capacity to stimulate wound regenerative processes. A review of the literature and our own observations

Dariusz Bazaliński 1, 2 , Mateusz Skórka 3 , Paulina Szymańska 4 , Anna Wójcik 1, 2 , Przemysław Lipiński 5

biofilm, defensins, Lucilia sericata, chronic wound

Dariusz Bazaliński

^{1, 2}

,

Mateusz Skórka

³

,

Paulina Szymańska

⁴

,

Anna Wójcik

^{1, 2}

,

Przemysław Lipiński

⁵