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Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii
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2/2023
vol. 39
 
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Review article

MDMA-assisted psychotherapy in the treatment of PTSD in adults – literature review

Monika Nowak
1
,
Julia Górczyńska
1
,
Michał Gebuza
1

  1. Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland; Wydział Lekarski, Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wrocław, Polska
Farmakoterapia w Psychiatrii i Neurologii 2023, 39 (2), 131–142
DOI: https://doi.org/10.5114/fpn.2023.133519
Online publish date: 2024/01/19
Article file
- 04GR_IPiN_FARM_2023-2B.pdf  [0.17 MB]
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1. Auxéméry Y. Post-traumatic psychiatric disorders: PTSD is not the only diagnosis. Presse Med 2018; 47 (5): 423-30.
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3. Benzenhöfer U, Passie T. Zur Frühgeschichte von „Ecstasy” [The early history of "Ecstasy"]. Nervenarzt 2006; 77 (1): 95-6, 98-9.
4. Cipriani A, Cowen PJ. 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in service personnel. Lancet Psychiatry 2018 Jun; 5 (6): 453-5.
5. Danforth AL, Grob CS, Struble C, Feduccia AA, Walker N, Jerome L et al. Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study. Psychopharmacology (Berl) 2018; 235 (11): 3137-48.
6. Feduccia AA, Mithoefer MC. MDMA-assisted psychotherapy for PTSD: Are memory reconsolidation and fear extinction underlying mechanisms? Prog Neuropsychopharmacol Biol Psychiatry 2018 ; 84 (Pt A): 221-8.
7. Harris DS, Baggott M, Mendelson JH, Mendelson JE, Jones RT. Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology (Berl) 2002 Aug; 162 (4): 396-405.
8. Hoskins M, Pearce J, Bethell A, Dankova L, Barbui C, Tol WA et al. Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis. Br J Psychiatry 2015 ; 206 (2): 93-100.
9. Kalant H. The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs. CMAJ 2001; 165 (7): 917-28.
10. Kozera K, Cichoń L, Wilczyński KM, Janas-Kozik M. MDMA – hopes and fears associated with therapeutic use in mental disorders. Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii 2020; 36 (3): 187-204.
11. Latimer D, Stocker MD, Sayers K, Green J, Kaye AM, Abd-Elsayed A et al. MDMA to Treat PTSD in Adults. Psychopharmacol Bull 2021;51 (3): 125-49.
12. Miller GM. The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J Neurochem 2011; 116 (2): 164-76.
13. Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med 2021; 27 (6): 1025-33.
14. Mithoefer MC, Feduccia AA, Jerome L, Mithoefer A, Wagner M, Walsh Z et al. MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology (Berl) 2019; 236 (9): 2735-45.
15. Mithoefer MC, Mithoefer AT, Feduccia AA, Jerome L, Wagner M, Wymer J et al. 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in military veterans, firefighters, and police officers: a randomised, double-blind, dose-response, phase 2 clinical trial. Lancet Psychiatry 2018; 5 (6): 486-97.
16. Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Doblin R. The safety and efficacy of {+/-}3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. J Psychopharmacol 2011; 25 (4): 439-52.
17. Oehen P, Gasser P. Using a MDMA- and LSD-Group Therapy Model in Clinical Practice in Switzerland and Highlighting the Treatment of Trauma-Related Disorders. Front Psychiatry 2022; 13: 863552.
18. Pallanti S, Mazzi D. MDMA (Ecstasy) precipitation of panic disorder. Biol Psychiatry 1992; 32 (1): 91-5.
19. Parrott AC. Human research on MDMA (3,4-methylene-dioxymethamphetamine) neurotoxicity: cognitive and behavioural indices of change. Neuropsychobiology 2000; 42 (1): 17-24.
20. Smith KW, Sicignano DJ, Hernandez AV, White CM. MDMA-Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta-Analysis. J Clin Pharmacol 2022; 62 (4): 463-71.
21. Tedesco S, Gajaram G, Chida S, Ahmad A, Pentak M, Kelada M et al. The Efficacy of MDMA (3,4-Methylenedioxymethamphetamine) for Post-traumatic Stress Disorder in Humans: A Systematic Review and Meta-Analysis. Cureus 2021; 13 (5): e15070. doi: 10.7759/cureus.15070.
22. Wagner AC, Mithoefer MC, Mithoefer AT, Monson CM. Combining Cognitive-Behavioral Conjoint Therapy for PTSD with 3,4-Methylenedioxymethamphetamine (MDMA): A Case Example. J Psychoactive Drugs 2019; 51 (2): 166-73.

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