eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
3/2015
vol. 19
 
Share:
Share:
Review paper

Malignant transformation of calcifying cystic odontogenic tumour – a review of literature

Bassel Tarakji
,
Nipun Ashok
,
Ibrahim Alzoghaibi
,
Mohammed Alsakran Altamimi
,
Saleh Nasser Azzeghaiby
,
Kusai Baroudi
,
Mohammad Zakaria Nassani

Contemp Oncol (Pozn) 2015; 19 (3): 184–186
Online publish date: 2015/07/08
Article file
- Malignant.pdf  [0.05 MB]
Get citation
 
PlumX metrics:
 

Introduction

A calcifying cystic odontogenic tumour (CCOT) is a heterogeneous group of lesions. It is a relatively rare odontogenic lesion which exists either as a cystic or a solid variant and is characterised by varied clinical, radiographical and biological features [1]. CCOT presents both central (intraosseous) and peripheral (extraosseous) locations. The central CCOT appears as a unilocular or multilocular destructive radiolucent lesion containing irregular calcifications [2]. Various terminologies used for CCOT include calcifying odontogenic cyst, Gorlin cyst, calcifying ghost cell odontogenic tumour and epithelial odontogenic ghost cell tumour, keratinizing calcifying odontogenic tumour [3].
In 2005, the World Health Organization Classification of Head and Neck Tumors reclassified CCOT as an odontogenic tumor and gave it the name of “calcifying cystic odontogenic tumor” [4]. CCOT has been classified as SNOMED code 930/0 [5].
Calcifying cystic odontogenic tumour is a developmental cyst of odontogenic origin and constitutes about 0.37% to 2% of all odontogenic tumours [2]. CCOT are cysts of primordial origin and not associated with crown of any impacted tooth. Cells believed to be responsible for the CCOT are rests of Serres [6]. CCOT may occur as a central lesion or as a peripheral lesion (although rare) [7].

Material and methods

A comprehensive review of the available literature relating to malignant transformation of CCOT was undertaken using Medline, PubMed, Google Scholar and SCOPUS in all languages. We used the following keywords for searching: calcifying cystic odontogenic tumour, malignancy and ghost cell odontogencic carcinoma from 2003–2013. We also used the “Related Articles” feature of PubMed to identify further references of interest within the primary search. These articles were obtained, and from their references lists, pertinent secondary references were also identified and acquired. The process was repeated until no further new articles could be identified. The abstracted literature was also reviewed. The type of manuscripts included was case reports and case series.

Results

Ghost cell odontogenic carcinoma (GCOC) is a rare tumour which is a malignant counterpart of CCOT [8]. Ghost cell odontogenic carcinoma may arise as a denovo tumour or from previously existing CCOT [9]. Ghost cell odontogenic carcinoma is seen to arise from CCOT after multiple recurrences [10]. One third cases of ghost cell odontogenic carcinoma are reported to be derived from a preexisting CCOT and malignant transformation may take several years [11]. However some of the ghost cell carcinoma may develop without history of CCOT [12–14].
Recurrent CCOT and GCOC are more common in the maxilla [8, 15]. Painful swelling with local paraesthesia is the most common symptom of ghost cell odontogenic carcinoma [12]. Some authors reported of infiltrative growth, root resorption and tooth displacements in cases of GCOC [16, 17]. Radiographic examinations showed a mixed radiolucent-radiopaque lesion with a moderately defined border. CT scan demonstrated bone expansion and bone destruction with irregularly shaped calcified inside the lesion. Magnetic resonance images showed a mass with high signal intensity [8].
Histopathological examination revealed acystic or solid appearance. Li et al. reported an ameloblastoma-like epithelia with prominent features being presence of lots of ghost cells, dysplastic uncalcified dentin or osteodentin. Increased nuclear/cytoplasmic ratio with 1–2 nucleoloi and atypical mitotic figures were also reported [18]. According to Motsugi et al., tumour cells densely proliferates the epithelial component and the nucleus of tumour cells were enlarged and variable in size [11].
Immunohistochemical analysis of GCOC by Motossugi et al. revealed that 70% of tumour cells were reactive for p53 and ki-67 index was 4% to28% [11]. Expression of ki-67, MMP-9 and TIMP-1 was stronger in GCOC when compared to CCOT [19]. MMP-9 in stroma is associated with invasive ability of CCOT and GCOC and ki-67 is associated with increased cellular proliferation. According to Gomes et al., there is a variable expression of syndecan-1 in stellate reticulum, stromal cells and basal cells of CCOT and GCOC and might be associated with the biology of these tumors [20].
A total of 8 cases have been reported in the literature from 2003-2013 where ghost cell odontogenic carcinoma has probably developed from CCOT. These cases are enlisted in Table 1 [8, 13, 14, 16–18, 21, 22].
Some cases of metastasis have been reported after GCOC. Of the 29 patients diagnosed, 5 died of local recurrence and metastasis to brain and lung has been reported [13]. The most commonly employed treatment was surgery with wide excision. In some cases radiotherapy and chemotherapy has been performed but their effectiveness was not evaluated [8].

Conclusions

After reviewing the literature we conclude that recurrent and long standing case of CCOT can undergo malignant transformation. GCOC, the malignant form of CCOT can metastasize and can even lead to deaths. So it is mandatory to follow up the patients with CCOT for possible eventual development of malignant counterparts.

Authors declare no conflict of interest.

References

1. Mittal N, Chandra S, Gupta S, Mittal S, Agarwal S. Extraosseous calcifying cystic odontogenic tumor: An uncommon variant. Natl J Maxillofac Surg 2013; 4: 245-8.
2. Wader J, Gajbi N. Neoplastic (solid) calcifying ghost cell tumor, intraosseous variant: report of a rare case and review of literature. J Clin Diagn Res 2013; 7: 1999-2000.
3. Sonone A, Sabane VS, Desai RV. Calcifying ghost cell odontogenic cyst: report of a case and review of literature. Case Rep Dent 2011; 2011: 328743.
4. Praetorius F, Ledesma-Montes C. Dentino- genic ghost cell tumour. In: World Health Or- ganization Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Barnes L, Eveson JW, Reichart P, Sidransky D (eds.). IARC Press, Lyon 2005; 314.
5. Tomich CE. Calcifying odontogenic cyst and dentinogenic ghost cell tumor. Oral Maxillofac Surg Clin North Am 2004; 16: 391-7.
6. Marx RE, Stern D. Odontogenic and nonodontogenic cysts. In: Oral and Maxillofacial Pathology: A Rationale for Diagnosis and Treatment. Quientessence Publishing, Hanover Park 2003; 607.
7. Resende RG, Brito JA, Souza LN, Gomez RS, Mesquita RA. Peripheral calcifying odontogenic cyst: a case report and review of the literature. Head and Neck Pathol 2011; 5: 76-80.
8. Arashiyama T, Kodama Y, Kobayashi T, Hoshina H, Takagi R, Hayashi T, Cheng J, Saku T. Ghost cell odontogenic carcinoma arising in the background of a benign calcifying cystic odontogenic tumor of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2012; 114: e35-e40.
9. Ledesma-Montes C, Gorlin RJ, Shear M, et al. International collaborative study on ghost cell odontogenic tumours: calcifying cystic odontogenic tumour,dentinogenic ghost cell tumour and ghost cell odontogenic carcinoma. J Oral Pathol Med 2008; 37: 302-8.
10. Li BB, Gao Y. Ghost cell odontogenic carcinoma transformed from a dentinogenic ghost cell tumor of maxilla after multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 691-695.
11. Motosugi U, Ogawa I, Yoda T, Abe T , Sugasawa M, MurataS, Yasuda M, Sakurai T, Shimizu Y, Shimizu M. Ghost cell odontogenic carcinoma arising in calcifying odontogenic cyst. Ann Diagn Pathol 2009; 13: 394-7.
12. Roh GS, Jeon BT, Park BW, Kim DR, Hah YS, Kim JH, Byun JH. Ghost cell odontogenic carcinoma of the mandible: a case report demonstrating expression of tartrateresistant acid phosphatase (TRAP) and vitronectin receptor. J Craniomaxillofac Surg 2008; 36: 419-23. 13.
Nazaretian SP, Schenberg ME, Simpson I, Slootweg PJ. Ghost cell odontogenic carcinoma. Int J Oral Maxillofac Surg 2007; 36: 455-8.
14. Sun ZJ, Zhao YF, Zhang L, Li ZB, Chen XM, Zhang WF. Odontogenic ghost cell carcinoma in the maxilla: a case report and literature review. J Oral Maxillofac Surg 2007; 65: 1820-4.
15. Li BB, Li TJ. Recurrence and malignant transformation of intraosseous dentinogenic ghost cell tumor. Beijing Da Xue Xue Bao 2011; 43: 48-51.
16. Cheng Y, Long X, Li X, Bian Z, Chen X, Yang X. Clinical and radiological features of odontogenic ghost cell carcinoma: Review of the literature and report of four newcases. Dentomaxillofac Radiol 2004; 33: 152-7.
17. Mokhtari S, Mohsenifar Z, Ghorbanpour M. Predictive factors of potential malignant transformation in recurrent calcifying cystic odontogenic tumor: reviewof the literature. Case Rep Pathol 2013; 853095: 1-6.
18. Li B, Gao Y. Ghost cell odontogenic carcinoma transformed from a dentinogenic ghost cell tumor of maxilla after multiple recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 107: 691-5.
19. Gong YL, Wang L, Wang HK, Li T, Chen XM. The expression of NF-kappaB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncol 2009; 45: 515-20.
20. Gomes da Silva W, Ribeiro Bartholomeu dos Santos TC, Cabral MG, Azevedo RS, Pires FR. Clinicopathologic analysisand syndecan-1 and k-67 expression in calcifying cystic odontogenic tumors, dentinogenic ghost cell tumor and ghost cell odontogenic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117: 626-33.
21. Li TJ, Yu SF. Clinicopathologic spectrum of the so-called calcifying odontogenic cysts: a study of 21 intraosseous cases with reconsideration of the terminology. Am J Surg Pathol 2003; 27: 372-384.
22. Goldenberg D, Sciubba J, Tufano RP. Odontogenic ghost cell carcinoma. Head Neck 2004; 26: 378-381.

Address for correspondence

Bassel Tarakji
Department of Oral Maxillofacial Sciences
Al-Farabi College of Dentistry and Nursing
Riyadh, Saudi Arabia
e-mail: denpol@yahoo.co.uk

Submitted: 9.03.2014
Accepted: 6.08.2014
Copyright: © 2015 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.