eISSN: 2449-8238
ISSN: 2392-1099
Clinical and Experimental Hepatology
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3/2017
vol. 3
 
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abstract:
Case report

Megamitochondria formation in hepatocytes of patient with chronic hepatitis C – a case report

Anna Wieczorek
,
Piotr M. Stępień
,
Dorota Zarębska-Michaluk
,
Wiesław Kryczka
,
Paweł Pabjan
,
Teodora Król

Clin Exp HEPATOL 2017; 3, 3: 169-175
DOI: https://doi.org/10.5114/ceh.2017.68287
Online publish date: 2017/06/12
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Although chronic hepatitis C virus (HCV) infection affect 185 million people world-wide, pathomechanism of liver damage is still unclear. Electron microscopy can reveal liver injury in very early stage and help understanding the mechanisms that is crucial in the pathogenesis of chronic hepatitis C. We present the morphological changes in the liver of HCV infected 24-year-old female patient, using light and transmission electron microscopy. Examination by TEM revealed wide range of specific subcellular abnormalities in hepatocellular ultrastructure. The most common observed changes were ring-shaped nuclei with intranuclear inclusion, megamitochondria, and “membranous web” structures – the hallmark of RNA-viruses infection.
keywords:

megamitochondria, HCV infection, hydropic degeneration, acidophilic degeneration, membranous web
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