Metformin in skin diseases

Damian Kadylak; Karina Polak; Kamila Wojciechowska; Beata Bergler-Czop

doi:10.5114/dr.2021.105891

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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1/2021
vol. 108

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abstract:

Review paper

Metformin in skin diseases

Damian Kadylak

¹

,

Karina Polak

¹

,

Kamila Wojciechowska

¹

,

Beata Bergler-Czop

²

The Dermatology Ward of the Independent Public “A. Mielêcki” Teaching Hospital, Katowice, Poland
Department of Dermatology, Silesian Medical University, Katowice, Poland

Dermatol Rev/Przegl Dermatol 2021, 108, 27-37

DOI: https://doi.org/10.5114/dr.2021.105891

Online publish date: 2021/05/13

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Metformin is the most widely used oral antidiabetic drug in the world. It is the first-line drug in type 2 diabetes, where its inhibiting effect on hepatic glucose production, increasing muscle and adipose tissue insulin sensitivity and reduction of glucose absorption in the gut are used. Many benefits to the skin condition have been reported from using metformin in dermatological diseases such as acne vulgaris, hidradenitis suppurativa, hirsutism as well as reducing the risk of certain skin malignancies and the occurrence of psoriasis. Some adverse effects of metformin have also been reported: rash, skin allergic reactions, drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), bullous pemphigoid, leukocytoclastic vasculitis, nail discoloration with subungual hyperkeratosis. The article is a review of currently available literature on the influence of metformin on the course of various skin diseases and its adverse effects.

keywords:

Metformin in skin diseases

Damian Kadylak 1 , Karina Polak 1 , Kamila Wojciechowska 1 , Beata Bergler-Czop 2

metformin, skin diseases, diabetes

Damian Kadylak

¹

,

Karina Polak

¹

,

Kamila Wojciechowska

¹

,

Beata Bergler-Czop

²