Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer

Anna Patla; Tomasz Walasek; Jerzy Jakubowicz; Paweł Blecharz; Jerzy Władysław Mituś; Anna Mucha-Małecka; Marian Reinfuss

doi:10.5114/wo.2015.51825

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2016
vol. 20

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abstract:

Review paper

Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer

Anna Patla

,

Tomasz Walasek

,

Jerzy Jakubowicz

,

Paweł Blecharz

,

Jerzy Władysław Mituś

,

Anna Mucha-Małecka

,

Marian Reinfuss

Contemp Oncol (Pozn) 2016; 20 (5): 358-364

DOI: https://doi.org/10.5114/wo.2015.51825

Online publish date: 2016/12/20

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This article presents methods and results of surgery and radiotherapy of brain metastases from non-small cell lung cancer (BMF-NSCLC). Patients with single BMF-NSCLC, with Karnofsky score ≥ 70 and controlled extracranial disease are the best candidates for surgery. Stereotactic radiosurgery (SRS) is recommended in patients with 1–3 BMF-NSCLC below 3–3.5 cm, with minor neurological symptoms, located in parts of the brain not accessible to surgery, with controlled extracranial disease. Whole brain radiotherapy (WBRT) following SRS reduces the risk of local relapse; in selected patients median survival reaches more than 10 months. Whole brain radiotherapy alone is

a treatment in patients with multiple metastases, poor performance status, uncontrolled extracranial disease, disqualified from surgery or SRS with median survival 3 to 6 months. There is no doubt that there are patients with BMF-NSCLC who should receive only the best supportive care. There is a debate in the literature on how to select these patients.

keywords:

Methods and results of locoregional treatment of brain metastases in patients with non-small cell lung cancer

Anna Patla , Tomasz Walasek , Jerzy Jakubowicz , Paweł Blecharz , Jerzy Władysław Mituś , Anna Mucha-Małecka , Marian Reinfuss

non-small cell lung cancer, brain metastases, radiation therapy

Anna Patla

,

Tomasz Walasek

,

Jerzy Jakubowicz

,

Paweł Blecharz

,

Jerzy Władysław Mituś

,

Anna Mucha-Małecka

,

Marian Reinfuss