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2/2020
vol. 95
 
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Original paper

Methylation status of leptin receptor gene promoter in obese children

Katarzyna Jakubek-Kipa
1
,
Natalia Potocka
2
,
Marzena Skrzypa
2
,
Łukasz Dembinski
3
,
Izabela Zawlik
2
,
Artur Mazur
1, 2

  1. II Clinic of Paediatrics, Endocrinology and Diabetology, Clinical Hospital no. 2 in Rzeszow, Rzeszow, Poland
  2. Centre for Innovative Research in Medical and Natural Sciences, Faculty of Medicine, University of Rzeszow, Rzeszow, Poland
  3. Department of Paediatric Gastroenterology and Nutrition, Medical University of Warsaw, Warsaw, Poland
Pediatr Pol 2020; 95 (2): 86–91
DOI: https://doi.org/10.5114/polp.2020.97117
Online publish date: 2020/07/10
Article file
- Methylation status.pdf  [0.17 MB]
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1. World Health Organization. Global Strategy on Diet, Physical Activity and Health. Available at: https://www.who.int/dietphysicalactivity/childhood/en/ (accessed: March 31, 2020).
2. Raj M, Kumar RK. Obesity in children & adolescents. Indian J Med Res 2010; 132: 598-607.
3. Herrera BM, Keildson S, Lindgren CM. Genetics and epigenetics of obesity. Maturitas 2011; 69: 41-49.
4. Zhang YY, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homolog. Nature 1994; 372: 425-432.
5. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
6. Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18: 213-215.
7. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999; 84: 3686-3695.
8. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.
9. Fernández-Riejos P, Najib S, Santos-Alvarez J, et al. Role of leptin in the activation of immune cells. Mediators Inflamm 2010; 2010: 568343.
10. Kumor A, Maciak I, Kozak-Michałowska I. Leptyna. Hormon o wielokierunkowym działaniu. Diag Lab 2004; 40: 179-190.
11. Strążynska A, Bryl W, Hoffmann K. Ocena stężenia leptyny, insuliny, parametrów gospodarki lipidowej i antropometrycznych u młodych osób z pierwotnym nadciśnieniem tętniczym. Nadciśnienie Tętnicze 2008; 12: 424-431.
12. Matarese G, Moschos S, Mantzoros CS. Leptin in immunology. J Immunol 2005; 174: 3137-3142.
13. Ahima RS, Qi Y, Singhal NS, et al. Brain adipocytokine action and metabolic regulation. Diabetes 2006; 55: S145-S54.
14. Ahima RS, Lazar MA. Adipocytokines and the peripheral and neutral control of energy balance. Mol Endocrinol 2008: 22: 1023-1031.
15. Baumann H, Morella KK, White DW. The full length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci 1996; 93: 8374-8378.
16. Baskin DG, Schwartz MW, Seeley RJ, et al. Leptin receptor long-form splice-variant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem 1999; 47: 353-362.
17. Lee GH, Proenca R, Montez JM, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
18. Fei H, Okano HJ, Li C, et al. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 1997; 94: 7001-7005.
19. Weinhold B. Epigenetics: the science of change. Environ Health Perspect 2006; 114: A160-167.
20. Goldberg AD, Allis CD, Bernstein E. Epigenetics: A landscape takes shape. Cell 2007; 128: 635-638.
21. Zhu J-K. Active DNA Demethylation Mediated by DNA Glycosylases. Annu Rev Genet 2009; 43: 143-166.
22. Jeltsch A. Molecular enzymology of mammalian DNA methyltransferases. Curr Top Microbiol Immunol 2006; 301: 203-225.
23. Moss TJ, Wallrath LL. Connections between epigenetic gene silencing and human disease. Mutat Res 2007; 618: 163-174.
24. Huang L, Li C. Leptin: a multifunctional hormone. Cell Res 2000; 10: 81-92.
25. Kułaga Z, Litwin M, Tkaczyk M, et al. Polish 2010 growth references for school-aged children and adolescents. Eur J Pediatr 2011; 170: 599-609.
26. MethPrimer®. Available at: http://www.urogene.org/methprimer2 (accessed: March 31, 2020).
27. Primer Design and Search Tool. Available at: http://bisearch.enzim.hu/ (accessed: March 31, 2020).
28. Melzner I, Scott V, Dorsch K, et al. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. J Biol Chem 2002; 277: 45420-45427.
29. Stoger R. In Vivo Methylation Patterns of the Leptin Promoter in Human and Mouse. Epigenetics 2006; 1: 155-162.
30. Plagemann A, Harder T. Hormonal programming in perinatal life: leptin and beyond. Br J Nutr 2009; 101: 151-152.
31. Krechowec SO, Vickers M, Gertler A, Breier BH. Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity.
32. J Endocrinol 2006; 189: 355-363.
33. Fan CN, Liu XL, Shen WW, et al. The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters. Nutr Metab (Lond) 2011; 8: 31.
34. Glendining KA, Higgins MBA, Fisher LC, Jasoni CL. Maternal obesity modulates sexually dimorphic epigenetic regulation and expression of leptin receptor in offspring hippocampus. Brain Behav Immun 2020 Mar 12; S0889-1591(19)31512-0. doi: 10.1016/j.bbi.2020.03.006 [Epub ahead of print].
35. Khalyfa A, Carreras A, Hakim F, et al. Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring. Int J Obes (Lond) 2013; 37: 1481-1489.
36. Campion J, Milagro FI, Martínez JA. Individuality and epigenetics in obesity. Obes Rev 2009; 10: 383-392.
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