MicroRNA-7 enhances cytotoxicity induced by gefitinib in non-small cell lung cancer via inhibiting the EGFR and IGF1R signalling pathways

Jun-gang Zhao; Wan-fu Men; Jun Tang

doi:10.5114/wo.2015.52655

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2015
vol. 19

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abstract:

Original paper

MicroRNA-7 enhances cytotoxicity induced by gefitinib in non-small cell lung cancer via inhibiting the EGFR and IGF1R signalling pathways

Jun-gang Zhao

,

Wan-fu Men

,

Jun Tang

Contemp Oncol (Pozn) 2015; 19 (3): 201–206

DOI: https://doi.org/10.5114/wo.2015.52655

Online publish date: 2015/07/08

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Gefitinib is a tyrosine kinase inhibitor that has been used for the treatment of non-small-cell lung carcinoma (NSCLC). The ability of miR-7 to enhance gefitinib-induced cytotoxicity in NSCLC cells was evaluated in this study. We found that miR-7 significantly decreased the IC50 of gefitinib and inhibited cell growth. G0/G1 cell cycle arrest and cell apoptosis were increased after the treatment of gefitinib coupled with miR-7 transfection. In addition, levels of Raf1, IGF1R, and PI3K and phosphorylation levels of Akt and ERK were also significantly decreased. Our results suggest that miR-7 may provide a novel therapeutic target for the treatment of NSCLCs.

keywords:

MicroRNA-7 enhances cytotoxicity induced by gefitinib in non-small cell lung cancer via inhibiting the EGFR and IGF1R signalling pathways

Jun-gang Zhao , Wan-fu Men , Jun Tang

non-small-cell lung carcinoma, gefitinib, miR-7, epidermal growth factor receptor

Jun-gang Zhao

,

Wan-fu Men

,

Jun Tang