MicroRNAs – novel biomarkers for malignant pleural effusions

Wiktor Wojczakowski; Dominik Kobylarek; Jacek Lindner; Nattakarn Limphaibool; Mariusz Kaczmarek

doi:10.5114/wo.2019.89241

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2019
vol. 23

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abstract:

Review paper

MicroRNAs – novel biomarkers for malignant pleural effusions

Wiktor Wojczakowski

¹

,

Dominik Kobylarek

¹

,

Jacek Lindner

¹

,

Nattakarn Limphaibool

¹

,

Mariusz Kaczmarek

²

Students Scientific Circle of Clinical Immunology, Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland
Department of Clinical Immunology, Poznan University of Medical Sciences, Poznan, Poland

Contemp Oncol (Pozn) 2019; 23 (3): 133-140

DOI: https://doi.org/10.5114/wo.2019.89241

Online publish date: 2019/10/30

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Lung cancer is one of the most common causes of cancer death. Its poor prognosis can be attributed to the patients’ advanced or metastatic presentation at the time of diagnosis. To improve and accelerate the diagnosis, better therapeutic and diagnostic methods are constantly being sought. MicroRNAs (miRNAs) are short nucleotide sequences of single-stranded, non-coding RNA that function as critical post-transcriptional regulators of gene expression. They are identified not only intracellularly, but also in physiological and pathological body fluids. These molecules are responsible for the regulation of approximately 33% of human genes, either regulating the expression of both oncogenes and suppressor genes or acting directly as an oncogene or suppressor gene itself. MiRNAs can contribute to the formation of cancer. The high specificity and sensitivity of miRNAs have been demonstrated with various malignant diseases, and for this reason, they raise particular interest as new and perspective biomarkers of tumours. Our work summarises the available information from recent years regarding the possibility of using miRNAs as biomarkers in the diagnosis of neoplasms. In this review, we focused on malignant pleural effusions with an emphasis on non-small cell lung cancer (NSCLC).

keywords:

MicroRNAs – novel biomarkers for malignant pleural effusions

Wiktor Wojczakowski 1 , Dominik Kobylarek 1 , Jacek Lindner 1 , Nattakarn Limphaibool 1 , Mariusz Kaczmarek 2

miRNA, lung cancer, pleural effusions, biomarker

Wiktor Wojczakowski

¹

,

Dominik Kobylarek

¹

,

Jacek Lindner

¹

,

Nattakarn Limphaibool

¹

,

Mariusz Kaczmarek

²