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4/2013
vol. 94 abstract:
Review paper
Microbial biotransformation of two phosphonoacetic acid derivatives bearing two stereomeric centres
Jagoda Szyszkowiak
,
Paulina Majewska
BioTechnologia vol. 94(4) C pp. 425-431 C 2013
Online publish date: 2014/10/23
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Three strains of microorganisms: Bacillus subtilis, Serratia liquefaciens and Escherichia coli were tested as
whole-cell biocatalysts for the kinetic resolution of isomers of two new phosphonoacetic acid derivatives. Used compounds possess two chiral centres – one at the carbon adjacent to both functional groups and the other at the phosphorus. Biocatalytic hydrolysis of 2-butyryloxy-2-(butoxyetoxyphosphinyl)acetic acid and 2-butyryloxy-2-(isobutoxyetoxyphosphinyl) acetic acid with whole cells of Bacillus subtilis produced corresponding hydroxyphosphonates with diastereoselectivity ranging from 50 to 60%. keywords:
hydroxyphosphonates, lipolytic activity, biotransformations |