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ISSN: 0860-7796
BioTechnologia
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4/2013
vol. 94
 
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abstract:
Review paper

Microbial biotransformation of two phosphonoacetic acid derivatives bearing two stereomeric centres

Jagoda Szyszkowiak
,
Paulina Majewska

BioTechnologia vol. 94(4) C pp. 425-431 C 2013
Online publish date: 2014/10/23
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Three strains of microorganisms: Bacillus subtilis, Serratia liquefaciens and Escherichia coli were tested as

whole-cell biocatalysts for the kinetic resolution of isomers of two new phosphonoacetic acid derivatives. Used

compounds possess two chiral centres – one at the carbon adjacent to both functional groups and the other at the

phosphorus. Biocatalytic hydrolysis of 2-butyryloxy-2-(butoxyetoxyphosphinyl)acetic acid and 2-butyryloxy-2-(isobutoxyetoxyphosphinyl)

acetic acid with whole cells of Bacillus subtilis produced corresponding hydroxyphosphonates

with diastereoselectivity ranging from 50 to 60%.
keywords:

hydroxyphosphonates, lipolytic activity, biotransformations



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