eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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2/2020
vol. 71
 
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abstract:
Case report

Microscopic extraovarian sex cord proliferation: report of a case with bilateral Fallopian tube involvement and a comprehensive molecular analysis

Pavel Dundr
1
,
Zuzana Věcková
1
,
Ivana Tichá
1
,
Jan Hojný
1
,
Kristýna Němejcová
1
,
Michaela Bártů
1

  1. Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic
Pol J Pathol 2020; 71 (2): 175-180
DOI: https://doi.org/10.5114/pjp.2020.97023
Online publish date: 2020/07/22
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We report a case of a 58-year-old female with microscopic extraovarian sex cord proliferations affecting both Fallopian tubes. Molecular analysis showed likely pathogenic germline missense mutations of the KDM5A and KMT2D genes. However, mutations of other genes, including FOXL2 and STK11, were not detected. Our case represents the 12th case of extraovarian sex cord proliferation reported in the literature to date. This is the first time that a molecular genetic analysis of the lesion has been performed, and it showed a wild-type FOXL2 gene, which represents another argument supporting the estimated benign nature of these rare lesions.
keywords:

extraovarian sex cord stromal proliferation, Fallopian tube, FOXL2
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