Mixed glandular-neuroendocrine cancer of the gallbladder. Report of a case

Adam Durczyński; Dariusz Szymański; Stanisław Sporny; Janusz Strzelczyk

doi:10.5114/wo.2011.20530

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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1/2011
vol. 15

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abstract:

Case report

Mixed glandular-neuroendocrine cancer of the gallbladder. Report of a case

Adam Durczyński

,

Dariusz Szymański

,

Stanisław Sporny

,

Janusz Strzelczyk

Contemporary Oncology (2011) vol. 15; 1 (40–43)

DOI: https://doi.org/10.5114/wo.2011.20530

Online publish date: 2011/03/11

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Here we present a unique case report of development of mixed glandular-neuroendocrine cancer four years after complete resection of advanced adenocarcinoma of the gallbladder in a 72-year-old woman. Primary treatment consisted of extended cholecystectomy with wedge resection of the gallbladder bed including more than 2 cm of normal liver and dissection of the regional lymph nodes. Recurrent tumour was treated by extended right hemihepatectomy and adjuvant chemotherapy. This case is the first description of mixed glandular-neuroendocrine cancer of the gallbladder and represents the long-term follow-up of a surviving patient with this stage of the disease. The authors discuss possible explanations of such a phenomenon and emphasize the need for evaluation of neuroendocrine differentiation in gallbladder carcinomas, which can be misdiagnosed, as it may be related to better prognosis, and may indicate the necessity of adjuvant chemotherapy application.

keywords:

Mixed glandular-neuroendocrine cancer of the gallbladder. Report of a case

Adam Durczyński , Dariusz Szymański , Stanisław Sporny , Janusz Strzelczyk

gallbladder, mixed tumour, neuroendocrine carcinoma, adenocarcinomas

Adam Durczyński

,

Dariusz Szymański

,

Stanisław Sporny

,

Janusz Strzelczyk