Molecular aspects of skin aging. Literature review

Michał Rogowski-Tylman; Joanna Narbutt; Anna Woźniacka; Aleksandra Lesiak

doi:10.5114/dr.2016.59136

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2016
vol. 103

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abstract:

Review paper

Molecular aspects of skin aging. Literature review

Michał Rogowski-Tylman

,

Joanna Narbutt

,

Anna Woźniacka

,

Aleksandra Lesiak

Przegl Dermatol 2016, 103, 139–142

DOI: https://doi.org/10.5114/dr.2016.59136

Online publish date: 2016/05/04

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Skin aging is a complex process composed of sequential phenomena which lead to structural and functional changes. There are many pathways leading to photoaging, but their mechanisms are not well elucidated. Matrix metalloproteinases are a family of proteases known to degrade collagen. Aged skin is accompanied by higher metalloproteinase production, leading to degradation of extracellular matrix. Another pathway of aging is the complex TGF-β/Smad. Transforming growth factor-β is the primary regulator of collagen synthesis in skin. It has been reported that UV irradiation impairs TGF-β/Smad signaling through downregulating the transcription. In recent literature cathepsins and progerin are the newest proteins reported to be involved in aging. Cathepsins are a group of proteases with collagenolytic and elastinolytic activities, but their role in photoaged skin is only partially known. Progerin is an abnormal form of lamin A. In recent studies, it is noted for its participation in the process of skin photoaging.

keywords:

Molecular aspects of skin aging. Literature review

Michał Rogowski-Tylman , Joanna Narbutt , Anna Woźniacka , Aleksandra Lesiak

skin aging, metalloproteinases, cathepsin K, progerin, transforming growth factor-β/Smad pathway

Michał Rogowski-Tylman

,

Joanna Narbutt

,

Anna Woźniacka

,

Aleksandra Lesiak