Molecular profiling of tumours for precision oncology – high hopes <i>versus</i> reality

Sergiusz Nawrocki

doi:10.5114/wo.2018.73873

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Contemporary Oncology

1/2018

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abstract:

Review paper

**Molecular profiling of tumours for precision oncology – high hopes versus reality**

Sergiusz Nawrocki

Contemp Oncol (Pozn) 2018; 22 (1A): 3–6

DOI: https://doi.org/10.5114/wo.2018.73873

Online publish date: 2018/03/08

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Treatment based on molecular profiling of tumor is advertised however there are very limited clinical data supporting this approach so far. Only one, relatively small, randomized clinical trial (SHIVA) have not met its primary endpoint - prolongation of PFS. Some other unpublished series were reported during ASCO 2017 and are discussed in this review. There are many issues to be resolved before the tumor profiling will enter the clinical practice with significant benefit for patients, eg. spatial and temporal heterogeneity of tumor cells in individual patient, wide access to targeted therapies, toxicity of combined targeted therapies.

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Molecular profiling of tumours for precision oncology – high hopes versus reality

Sergiusz Nawrocki

tumor profiling, targeted therapies

**Molecular profiling of tumours for precision oncology – high hopes versus reality**