eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
3/2022
vol. 73
 
Share:
Send email
Share:
abstract:
Original paper

Morphology of cells undergoing epithelial mesenchymal transition in microinvasive and early invasive oral squamous cell carcinom a – a light microscopic study

Ketki Kalele
1
,
Vaishnavi Bhondekar
2
,
Shruti Dongare
2
,
Wasim Khan
3
,
Ashwini Shelotkar
3
,
Kaustubh Badukale
4
,
Kanchan Damare
5

  1. Neuron Institute of Applied Research, Amravati, India
  2. Dental College and Hospital, Amravati, India
  3. Sant Gadge Baba Amravati University, Amravati, India
  4. Rajiv Gandhi Institute of IT and Bio-technology, Pune, India
  5. Brijlal Biyani Science College, Amravati, India
Pol J Pathol 2022; 73 (3): 244-254
DOI: https://doi.org/10.5114/pjp.2022.124491
Online publish date: 2023/01/10
View full text Get citation
 
PlumX metrics:
The present study focuses on identification of cancer attributes of epithelial mesenchymal transition (EMT) at the earliest possible stage (microinvasion) under a light microscope by using hematoxylin and eosin stains, making it feasible for researchers to investigate such cases with ease without the use of extensive setups. The present study is the first in the English literature to define EMT features in micro-invasive and early invasive oral squamous cell carcinoma (OSCC) under a light microscope.

This is a retrospective study of histological sections of 43 cases of OSCC from the Department of Oral Pathology and Microbiology. The data collected were later statistically analyzed.

A total of 11 micro-invasive and 32 early invasive OSCC cases were assessed for core features of EMT.

The predominant feature defining EMT found was dense inflammatory infiltrate in both microinvasive (91%) and early invasive OSCC (88%) followed by cell individualization in 82% of microinvasive and 75% of early invasive OSCC, which was then followed by other features.

Reporting EMT in histopathological reports on a daily basis can aid in early diagnosis of OSCC as well as understanding carcinogenesis in early stages. Thereby, inclusion of EMT targeting therapeutics in early stages of OSCC can significantly alter the prognosis of cancer.
keywords:

EMT, microinvasive OSCC, early invasive OSCC, loss of apical basal polarity, cell-to-cell adhesion weakening, cell individualization, established front back polarity, dense inflammatory cell infiltration
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.