Myeloid sarcoma in children – diagnostic and therapeutic difficulties

Magdalena Samborska; Katarzyna Derwich; Jolanta Skalska-Sadowska; Paweł Kurzawa; Jacek Wachowiak

doi:10.5114/wo.2016.65602

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

6/2016
vol. 20

Send email

Copy url:

abstract:

Review paper

Myeloid sarcoma in children – diagnostic and therapeutic difficulties

Magdalena Samborska

,

Katarzyna Derwich

,

Jolanta Skalska-Sadowska

,

Paweł Kurzawa

,

Jacek Wachowiak

Contemp Oncol (Pozn) 2016; 20 (6): 444–448

DOI: https://doi.org/10.5114/wo.2016.65602

Online publish date: 2017/01/30

View full text Get citation

PlumX metrics:

Myeloid sarcoma (MS) is a malignant extramedullary tumour, which consists of immature cells of myeloid origin. It may occur de novo, concurrently or precede the diagnosis of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) or chronic myeloid leukemia (CML). MS can also be a manifestation of the relapse of the disease. The more frequent sites of involvement are the skin, orbit, bone, periosteum, lymph nodes, gastrointestinal tract, soft tissue, central nervous system and testis. Because of its different localization and symptoms, and the lack of diagnostics algorithm, myeloid sarcoma is a real diagnostic challenge, in particular in patients without initial bone marrow involvement. The correct diagnosis of MS is important for adequate therapy, which is often delayed because of a high misdiagnosis rate. In the paper, the role of immunohistochemistry, cytogenetic and molecular genetic analyses is emphasized as well as the breadth of unclear aspects of this disorder in children.

keywords:

Myeloid sarcoma in children – diagnostic and therapeutic difficulties

Magdalena Samborska , Katarzyna Derwich , Jolanta Skalska-Sadowska , Paweł Kurzawa , Jacek Wachowiak

myeloid sarcoma, children, diagnosis, therapy

Magdalena Samborska

,

Katarzyna Derwich

,

Jolanta Skalska-Sadowska

,

Paweł Kurzawa

,

Jacek Wachowiak