Neoadjuvant radiochemotherapy in squamous cell cancer 	of the esophagus – morphological assessment and clinical results

Andrzej Bernacki; Jacek Nikliński; Jerzy Laudański; Krzysztof Furman; Marian Furman; Mirosław Kozłowski; Stanisław Kiluk

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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2/2000
vol. 4

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abstract:

Neoadjuvant radiochemotherapy in squamous cell cancer of the esophagus – morphological assessment and clinical results

Andrzej Bernacki

,

Jacek Nikliński

,

Jerzy Laudański

,

Krzysztof Furman

,

Marian Furman

,

Mirosław Kozłowski

,

Stanisław Kiluk

Współcz Onkol (2000) vol. 4, 2 (58-60)

Online publish date: 2003/07/25

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The study was perfomed in 37 pateints with squamous cell carcinoma of the esophagus in two groups. In group I – 12 patients received no preoperative treatment, in group II – in 25 patients preoperative concurrent radiotherapy (200 cGy/day to tatal dose of 3000 cGy) and chemotherapy (Cisplatin – on days 1 to 5 and 17 to 21 at a dose of 20 mg/m²/day and 5-Fluorouracyl continuous i. v. infusion of 300 mg/m²/day) were administered. In group II after operation in 4 patients microscopic examination revealed no presence of cancer cells – complete response (CR). Of twelve patients with reduction of neoplastic infiltration 7 had partial response 1 (PR1) and 5 had partial response 2 (PR2). In 7 patients no changes were detected – stable disease (SD). In clinical examination we assessed – stage of the disease (pTNM), postoperative complications and 2-years survival. 27% of the patients in group I and 48% of patients in group II survived 2 years after the operation.

Conclusions: Neoadjuvant radiochemotherapy improves 2-years survival rate in squamous cell esophageal cancer. Long term clinical results correlate with the response of the tumour to the preoperative treatment.

keywords:

Neoadjuvant radiochemotherapy in squamous cell cancer of the esophagus – morphological assessment and clinical results

Andrzej Bernacki , Jacek Nikliński , Jerzy Laudański , Krzysztof Furman , Marian Furman , Mirosław Kozłowski , Stanisław Kiluk

esophageal cancer, neoadjuvant radiochemotherapy

Andrzej Bernacki

,

Jacek Nikliński

,

Jerzy Laudański

,

Krzysztof Furman

,

Marian Furman

,

Mirosław Kozłowski

,

Stanisław Kiluk