Neurofilaments and traumatic brain injury

Mariusz Kobek; Rafał Skowronek; Zbigniew Jankowski; Artur Pałasz

doi:10.5114/amsik.2014.50531

eISSN: 1689-1716
ISSN: 0324-8267

Archiwum Medycyny Sądowej i Kryminologii/Archives of Forensic Medicine and Criminology

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4/2014
vol. 64

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abstract:

Review paper

Neurofilaments and traumatic brain injury

Mariusz Kobek

,

Rafał Skowronek

,

Zbigniew Jankowski

,

Artur Pałasz

Arch Med Sąd Kryminol 2014; 64 (4): 268–279

DOI: https://doi.org/10.5114/amsik.2014.50531

Online publish date: 2015/03/31

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Objective determination of the time of brain contusion is of key importance in medicolegal neurotraumatology. Currently, the progress of immunohistochemistry allows the study of structural elements of cells including neurofilaments, i.e. neuronal cytoskeletal proteins possessing properties that could be used for determining the age of brain injury in forensic medicine.

The purpose of this study was to review recently published literature with a focus on studies investigating changes which occur in neurofilaments after brain trauma, both in animal models and in human biological material. The review has shown a lack of data on temporal changes in neurofilament expression after human brain trauma which could be used for determining the age of injuries in forensic medicine.

keywords:

Neurofilaments and traumatic brain injury

Mariusz Kobek , Rafał Skowronek , Zbigniew Jankowski , Artur Pałasz

neurostructure, neurofilaments, traumatic brain injury, forensic medicine, immunohistochemistry

Mariusz Kobek

,

Rafał Skowronek

,

Zbigniew Jankowski

,

Artur Pałasz