eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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4/2023
vol. 19
 
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abstract:
Original paper

Neutrophil and lymphocyte count as predictors of the location of calcific coronary lesions in patients treated with rotational atherectomy

Michał Lesiak
1
,
Tomasz K. Urbanowicz
2
,
Anna Olasińska-Wiśniewska
2
,
Michal Michalak
3
,
Marek Grygier
1
,
Krzysztof J. Filipiak
4, 5

  1. 1st Cardiology Department, Poznan University of Medical Sciences, Poznan, Poland
  2. Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznan, Poland
  3. Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland
  4. Institute of Clinical Science, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland
  5. Department of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland
Adv Interv Cardiol 2023; 19, 4 (74): 343–350
DOI: https://doi.org/10.5114/aic.2023.133809
Online publish date: 2023/12/22
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Introduction:
The role of immune system activation in development and progression of atherosclerotic plaques has been postulated. Previous studies on inflammation have focused on the severity of coronary disease, the risk of acute coronary syndrome, and the prediction of outcomes based on hematological indices obtained from whole blood count analysis.

Aim:
To analyze simple data of the whole blood count in relation to the location of calcified atherosclerotic lesions in patients treated with coronary rotational atherectomy (RA).

Material and methods:
Eighty-one patients (57 (70%) males, mean (SD) age of 70.4 8 years) who underwent RA were enrolled in the study. The study group was divided into two subgroups depending on the proximal (group 1) and non-proximal (group 2) location of the culprit lesions in coronary arteries. The angiographic results were compared with demographic and clinical data and whole blood count analysis.

Results:
The multivariable analysis revealed the predictive value of low neutrophil (OR = 0.75, 95% CI: 0.58–0.97, p = 0.030) and lymphocyte counts (OR = 0.27, 95% CI: 0.11–0.68, p = 0.005) for the proximal location of the culprit lesions. In the ROC analysis, combined neutrophil and lymphocyte counts showed the best prediction of proximal location, with the area under the curve of 0.747 (p < 0.001), yielding a sensitivity of 79.07% and specificity of 73.68%.

Conclusions:
The lower neutrophil and lymphocyte counts in peripheral blood count analysis may be more representative of proximal calcified coronary lesions. The relationship between neutrophil and lymphocyte blood count and calcific atherosclerotic plaque location can indicate the inflammatory background of epicardial atheroma formation and distribution.

keywords:

lymphocyte, coronary disease, rotational atherectomy, neutrophil
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