eISSN: 2299-0038
ISSN: 1643-8876
Menopause Review/Przegląd Menopauzalny
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank


Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
6/2004
vol. 3
 
Share:
Send email
Share:
abstract:

Microsatellite instability in breast carcinoma

Beata Smolarz
,
Hanna Romanowicz-Makowska
,
Elżbieta Kozłowska
,
Marek Zadrożny
,
Tomasz Stetkiewicz
,
Tomasz Pertyński
,
Andrzej Kulig

Prz Menopauz 2004; 6: 40–46
Online publish date: 2004/12/16
View full text Get citation
 
Background: Microsatellite instability (MSI) is due to defective DNA mismatch repair. Defects in DNA mismatch-repair (MMR) genes lead to replication errors revealed as instability in microsatellite markers. Studies have shown that both hereditary breast cancer and sporadic breast cancer may be associated with mutations in a mismatch repair genes, such as MSH2, MLH1, PMS1, PMS2 and MSH6.
Approach: Results from studies that assayed microsatellite instability in hereditary and sporadic breast cancer are reviewed.
Conlusion: Several data suggest that microsatellite instability seem to be a risk factor both breast cancer in subjects belonged to HNPCC (Hereditary Nonpyloposis Colorectal Cancer) families with high incidence of this cancer and sporadic breast cancer.
keywords:

breast cancer, MMR genes, microsatellite instability, PCR
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.