eISSN: 1897-4252
ISSN: 1731-5530
Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery
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2/2007
vol. 4
 
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abstract:

Niewydolność serca i płuc, transplantologia
Bronchiolitis obliterans syndrome – current prophylaxis and treatment possibilities

Maria Lizak
,
Edward Nash
,
Cecilia Chapparro Mutis
,
Michael Hutcheon
,
Marian Zembala
,
Shaf Keshavjee

Kardiochirurgia i Torakochirurgia Polska 2007; 4 (2): 175–180
Online publish date: 2007/06/22
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Bronchiolitis obliterans syndrome (BOS) treatment remains the „Holy Grail” of lung transplantation. In this article the authors attempt to summarize the results of different immunosuppressive strategies aiming to prevent onset, delay progression and improve prognosis of BOS. Strategies discussed include switching cyclosporine (CSA) to tacrolimus (Tac), azathioprine (AZA) to mycophenolate mofetil (MMF), addition of sirolimus/rapamycin (Sir/Rapa), everolimus, azithromycin (AZI), inhaled steroids, inhaled cyclosporine, cytolytic therapy, photopheresis and total lymphoid irradiation (TLI).
keywords:

lung transplantation, bronchiolitis obliterans syndrome, immunosuppression

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