Nitric oxide – a pro-inflammatory and anti-inflammatory mediator

Ewa Marcinkiewicz; Janusz Marcinkiewicz; Stefan Chłopicki

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2003
vol. 28

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abstract:

Nitric oxide – a pro-inflammatory and anti-inflammatory mediator

Ewa Marcinkiewicz

,

Janusz Marcinkiewicz

,

Stefan Chłopicki

(Centr Eur J Immunol 2003; 28(2): 74–78)

Online publish date: 2004/01/20

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Abstract

NO is an ubiquitous mediator in cardiovascular, nervous and immune systems. Here we briefly review the role of NO in chronic inflammation and septic shock. In particular, we present the evidence that the double nature of NO resulting in its pro-inflammatory and anti-inflammatory action can be rather explained by oxidant stress environment and formation of secondary products of NO then by a double nature of NO itself.

keywords:

Nitric oxide – a pro-inflammatory and anti-inflammatory mediator

Ewa Marcinkiewicz , Janusz Marcinkiewicz , Stefan Chłopicki

nitric oxide, inflammation, reactive oxygen species, reactive nitrogen oxide species, septic shock

Ewa Marcinkiewicz

,

Janusz Marcinkiewicz

,

Stefan Chłopicki