eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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3/2017
vol. 13
 
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abstract:
Original paper

Nonalcoholic fatty liver disease as a predictor of atrial fibrillation: a systematic review and meta-analysis

Yaqiong Zhou
,
Chenglin Lai
,
Chunrong Peng
,
Mingyue Chen
,
Bolin Li
,
Xiaoyun Wang
,
Jingjing Sun
,
Chaofeng Sun

Adv Interv Cardiol 2017; 13, 3 (49): 250–257
DOI: https://doi.org/10.5114/aic.2017.70198
Online publish date: 2017/09/25
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Introduction: Numerous epidemiologic studies have investigated the link between nonalcoholic fatty liver disease (NAFLD) and long-term atrial fibrillation (AF) risk, but the results are surprisingly conflicting.

Aim: Therefore, we systematically reviewed all published studies assessing the risk of AF in patients with NAFLD and conducted a meta-analysis.

Material and methods: We performed a literature search using PubMed, EMBASE and Cochrane Library databases in February 2017 with no restrictions. Two cohort studies and two cross-sectional studies were identified, involving a total of 5150 subjects (NAFLD: 1655; controls: 3495) in this meta-analysis. Data from selected studies were extracted and a meta-analysis was performed using a random effects model.

Results: Nonalcoholic fatty liver disease patients had a significantly higher risk of AF compared to controls (relative risk (RR): 2.61; 95% confidence interval (CI): 1.34–5.06, p = 0.00; I2 = 52.5%, p = 0.097). In a further analysis stratified by presence of type 2 diabetes, the increased risk was present predominantly in patients with type 2 diabetes (RR = 5.10; 95% CI: 2.43–10.7, p < 0.001; I2 = 0, p = 0.958). However, subjects without type 2 diabetes were at slightly increased risk of AF but the relative risk did not reach statistical significance (RR = 1.68; 95% CI: 0.99–2.82, p = 0.05; I2 = 0, p = 0.461).

Conclusions: Our meta-analysis suggested that ultrasound-diagnosed NAFLD patients have a significantly higher risk for AF after adjustment for numerous important clinical risk factors for AF. These results need to be confirmed in large prospective studies.
keywords:

nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic cirrhosis, atrial arrhythmia, atrial fibrillation, atrial flutter
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