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Pharmacotherapy in Psychiatry and Neurology/Farmakoterapia w Psychiatrii i Neurologii
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2/2023
vol. 39
 
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Review article

Nutrition and cognitive function in the elderly population

Monika Bidzan-Wiącek
1
,
Leszek Bidzan
2

  1. Zakład Bioenergetyki i Fizjologii Wysiłku Fizycznego Gdańskiego Uniwersytetu Medycznego
  2. Klinika Psychiatrii Rozwojowej, Zaburzeń Psychotycznych i Wieku Podeszłego Gdańskiego Uniwersytetu Medycznego
Farmakoterapia w Psychiatrii i Neurologii 2023, 39 (2), 187–201
Online publish date: 2024/01/19
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1. Alzheimer’s Disease International. World Alzheimer Report 2019. Attitudes to dementia. https://www.alz.co.uk/research/world-report
2. Annweiler C, Schott AM, Allali G, Bridenbaugh SA, Kressig RW, Allain P, et al. Association of vitamin D deficiency with cognitive impairment in older women. Cross-sectional study. Neurology 2010; 74: 27–32.
3. Bäckman L, Jones S, Berger AK, Laukka EJ, Small BJ. Cognitive impairment in preclinical Alzheimer’s disease: A meta-analysis. Neuropsychology 2005; 19: 520–31.
4. Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer’s disease incidence. Lancet Neurol 2011; 10: 819–28.
5. Bensalem J, Dal-Pan A, Gillard E, Calon F, Pallet V. Protective effects of berry polyphenols against age-related cognitive impairment. Nutrition and Aging 2016; 3: 89–106.
6. Bertelli AA, Migliori M, Panichi V, Longoni B, Origlia N, Ferretti A et al. Oxidative stress and inflammatory reaction modulation by white wine. Ann NY Acad Sci 2002; 957: 295–301.
7. Bidzan M, Bidzan L: Masa ciała a zaburzenia czynności poznawczych. Neuropsychiatria i Neuropsychologia 2020; 15, 1–2: 51–9.
8. Blair SN, Jacobs Jr DR, Powell KE. Relationships between exercise or physical activity and other health behaviors. Public Health Rep 1985; 100: 172–80.
9. Blum S, Aviram M, Ben-Amotz A, Levy Y. Effect of a Mediterranean meal on postprandial carotenoids, paraoxonase activity and C-reactive protein levels. Ann Nutr Metab 2006; 50: 20–4.
10. Blumenthal JA, Smith PJ, Welsh-Bohmer K, Craighead L, Welsh-Bohmer KA, Browndyke JN, et al. Can lifestyle modification improve neurocognition? Rationale and design of the ENLIGHTEN clinical trial. Contemporary clinical trials 2013; 34: 60–9.
11. Boison D. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017; 30: 187–92.
12. Bond V, Curry BH, Adams RG, Asadi MS, Millis RM, Haddad GE. Effects of dietary nitrates on systemic and cerebrovascular hemodynamics. Cardiol Res Pract 2013; 2013: 435629.
13. de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med 2019; 381: 2541–51.
14. Chen JC, Ho FM, Pei-Dawn LC. Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia. Eur J Pharmacol 2005; 521: 9–20.
15. Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME, et al. The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: a preliminary randomised double-blind placebocontrolled study. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1538–44.
16. Cremonini AL, Caffa I, Cea M. Nutrients in the Prevention of Alzheimer’s Disease. Oxid Med Cell Longev 2019; 2019: 9874159.
17. Chrysohoou C, Panagiotakos DB, Pitsavos C, Das UN, Stefanadis C. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA Study. J Am Coll Cardiol 2004; 44: 152–8.
18. Colditz GA, Philpott SE, Hankinson SE. The Impact of the Nurses’ Health Study on Population Health: Prevention, Translation, and Control. Am J Public Health. 2016; 106: 1540–5.
19. Cunnane SC, Courchesne-Loyer A, Vandenberghe C, St-Pierre V, Fortier M, Hennebelle M, et al. Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of Alzheimer’s disease. Front Mol Neurosci 2016; 9: 53.
20. Currenti W, Godos J, Castellano S, Caruso G, Ferri R, Caraci F, et al. Association between Time Restricted Feeding and Cognitive Status in Older Italian Adults. Nutrients 2021; 13 (1): 191.
21. Grant WB. Trends in diet and Alzheimer’s disease during the nutrition transition in Japan and developing countries. J Alzheimer’s Dis 2014; 38: 611–20.
22. Devranis P, Vassilopoulou Ε, Tsironis V, Sotiriadis PM, Chourdakis M, Aivaliotis M et al. Mediterranean Diet, Ketogenic Diet or MIND Diet for Aging Populations with Cognitive Decline: A Systematic Review. Life (Basel). 2023; 13 (1): 173.
23. Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, et al. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiology of Aging 1992; 13: 179–89.
24. Diether NE, Willing BP. Microbial Fermentation of Dietary Protein: An Important Factor in Diet–Microbe–Host Interaction. Microorganisms 2019; 7: 19.
25. Drachman DA. If we live long enough, will we all be demented? Neurology 1994; 44: 1563–5.
26. Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G, et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 2004; 292: 1440–46.
27. Estruch R, Ros E, Salas-Salvado J, Covas MI, Corella D, Aros F et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013; 368: 1279–90.
28. Farrer LA, Cupples LA, Haines JL. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis. JAMA 1997; 278: 1349–56.
29. Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF et al. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA 2009; 302: 638–48.
30. Fito M, Cladellas M, de la Torre R, Martí J, Alcántara M, Pujadas-Bastardes M,
31. et al. Antioxidant effect of virgin olive oil in patients with stable coronary heart disease: a randomized, crossover, controlled, clinical trial. Atherosclerosis 2005; 181: 149–58.
32. Fontana L, Partridge L. Promoting health and longevity through diet: from model organisms to humans. Cell 2015; 161: 106–18.
33. Fung TT, McCullough ML, Newby P, Manson JE, Meigs JB, Rifai N,
34. et al. Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 2005; 82: 163–73.
35. Gauthier S, Reisberg B, Zaudig M. Mild cognitive impairment. Lancet 2006; 367: 1262–70.
36. Gillette-Guyonnet S, Vellas B. Caloric restriction and brain function. Curr Opin Clin Nutr Metab Care 2008; 11: 686–92.
37. Gluhm S, Goldstein J, Loc K, Colt A, Van Liew C, Corey-Bloom J. Cognitive Performance on the Mini-Mental State Examination and the Montreal Cognitive Assessment Across the Healthy Adult Lifespan. Cogn Behav Neurol. 2013 Mar; 26(1): 1–5.
38. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, et al. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 2011; 42: 2672–713.
39. Greenwood CE, Tam C, Chan M. Behavioral disturbances, not cognitive deterioration, are associated with altered food selection in seniors with Alzheimer’s disease. J Gerontol A Biol Sci Med Sci 2005; 60: 499–505.
40. Hardman RJ, Kennedy G, Macpherson H. A randomised controlled trial investigating the effects of Mediterranean diet and aerobic exercise on cognition in cognitively healthy older people living independently within aged care facilities: the Lifestyle Intervention in Independent Living Aged Care (LIILAC) study protocol [ACTRN12614001133628]. Nutr J 2015; 14: 53.
41. Halyburton AK, Brinkworth GD, Wilson CJ, Noakes M, Buckley JD, Keogh JB, et al. Low- and high-carbohydrate weight-loss diets have similar effects on mood but not cognitive performance. Am J Clin Nutr 2007; 86: 580–87.
42. Hersant H, Grossberg G. The Ketogenic Diet and Alzheimer’s Disease. J Nutr Health Aging 2022; 26(6): 606-14.
43. Hill E, Cliftond P, Goodwilla AM, Dennerstein L, Campbell S, Szoeke C. Dietary patterns and b-amyloid deposition in aging Australian women. Alzheimer’s & Dementia: Translational Research & Clinical Interventions 2018; 4: 535–41.
44. Horrne BD, Muhlestein JB, Anderson J. Health effects of intermittent fasting: hormesis or harm? A systematic review. Am J Clin. Nutr 2015; 102: 464–70.
45. Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease. Alzheimers Dement 2014; 10: 844–52.
46. Jiang C, Li G, Huang P, Liu Z, Zhao B. The Gut Microbiota and Alzheimer’s Disease. J Alzheimers Dis 2017; 58: 1–15.
47. Johnstone A. Fasting for weight loss: an effective strategy or latest dieting trend? Int J Obes 2015; 39: 727–33.
48. Kesse-Guyot E, Andreeva VA, Lassale C, Ferry M, Jeandel C, Hercberg S
49. et al. Mediterranean diet and cognitive function: a French study. Am J Clin Nutr 2013; 97: 369–76.
50. Li J, Li R, Lian X, Han P, Liu Y, Liu C et al. Time restricted feeding is associated with poor performance in specific cognitive domains of suburb-dwelling older Chinese. Sci Rep. 2023; 13 (1): 387.
51. Lilamand M, Porte B, Cognat E, Hugon J, Mouton-Liger F, Paquet C. Are ketogenic diets promising for Alzheimer’s disease? A translational review 2020; 12 (1): 42.
52. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, et al. Dementia prevention, intervention, and care. Lancet 2017; 390: 2673–734.
53. Li L, Wang Z, Zuo Z. Chronic Intermittent Fasting Improves Cognitive Functions and Brain Structures in Mice. PLoS One 2013; 8: e66069.
54. Loef M, von Stillfried N, Walach H. Zinc diet and Alzheimer’s disease: a systematic review. Nutr Neurosci 2012; 15: 2–12.
55. Luchsinger JA, Tang MX, Shea S, Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 2003; 60: 203–8.
56. Luchsinger JA, Tang MX, Shea S, Mayeux R. Caloric intake and the risk of Alzheimer disease. Arch Neurol 2002; 59: 1258–63.
57. Luchsinger JA, Tang MX, Shea S, Mayeux R. Hyperinsulinemia and risk of Alzheimer disease. Neurology 2004; 63: 1187–92.
58. Magaki S, Mueller C, Dickson C, Kirsch W. Increased production of inflammatory cytokines in mild cognitive impairment. Exp Gerontol 2007; 42(3), 233–40 (2007).
59. Martin CK, Anton SD, Han H, York-Crowe E, Redman LM, Ravussin E, et al. Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial. Rejuvenation Res 2007; 10: 179–90.
60. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL,
61. et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012; 489: 318–21.
62. Mattson MP. Lifelong brain health is a lifelong challenge: from evolutionary principles to empirical evidence. Ageing Res Rev 2015; 20: 37–45.
63. Mayeux R, Sano M, Chen J, Tatemichi T, Stern Y. Risk of dementia in first-degree relatives of patients with Alzheimer’s disease and related disorders. Arch Neurol 1991; 48: 269–73.
64. McCay CM, Mary F. Crowell MF, Maynard LA. The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size: One Figure. The Journal of Nutrition 1935; 10: 63–79.
65. Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of miceand men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev 2012; 11: 390–98.
66. Mentzelou M, Dakanalis A, Vasios GK, Gialeli M, Papadopoulou SK, Giaginis C. The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice. Nutrients 2023 May 11; 15 (10): 2270.
67. Molteni R, Barnard RJ, Ying Z, Roberts CK, Gómez-Pinilla F. A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning. Neuroscience 2002; 112: 803–14.
68. Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, et al. MIND diet associated with reduced incidence of Alzheimer’s disease. Alzheimers Dement 2015; 11: 1007–14.
69. Mosconi L, Murray J, Tsui WH, Li Y , Davies M, Williams S et al. Mediterranean Diet and Magnetic Resonance Imaging-Assessed Brain Atrophy in Cognitively Normal Individuals at Risk for Alzheimer’s Disease. J Prev Alzheimers Dis 2014; 1: 23–32.
70. Nutaitis AC, Tharwani SD, Serra MC. Diet as a risk factor for cognitive decline in African Americans and Caucasians with a parental history of Alzheimer’s disease: a cross- sectional pilot study dietary patterns. J Prev Alz Dis 2019; 6: 50–5.
71. Nasaruddin ML, Halim SA, Kamaruzzaman MA. Studying the Relationship of Intermittent Fasting and β-Amyloid in Animal Model of Alzheimer’s Disease: A Scoping Review. Nutrients 2020; 12: 3215.
72. Ng F, Wijaya L, Tang BL. SIRT1 in the brain-connections with aging-associated disorders and lifespan. Front Cell Neurosci 2015; 9: 64.
73. Ooi TC, Meramat A, Rajab NF, Shahar S, Ismail IS , Azam AA, et al. Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study. Nutrients 2020; 12: 2644.
74. Petersson SD. Mediterranean Diet, Cognitive Function, and Dementia: A Systematic Review of the Evidence. Advances in Nutrition 2016; 7: 889–904.
75. Phillips MC. Fasting as a Therapy in Neurological Disease. Nutrients 2019; 11: 2501.
76. Prince MJ, Wimo A, Guerchet MM, Ali GC, Wu YT, Prina M. World Alzheimer Report 2015 – The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends. Alzheimer’s Dis Int 2015; 84.
77. Psaltopoulou T, Naska A, Orfanos P, Trichopoulos D, Mountokalakis T, Trichopoulou A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. Am J Clin Nutr 2004; 80: 1012–18.
78. Rajan KB, Wilson RS, Weuve J, Barnes LL, Evans DA. Cognitive impairment 18 years before clinical diagnosis of Alzheimer disease dementia. Neurology 2015; 85: 898–904.
79. Schöll M, Lockhart SN, Schonhaut DR, O’Neil JP, Janabi M, Ossenkoppele R,
80. et al. PET Imaging of Tau Deposition in the Aging Human Brain. Neuron 2016; 89: 971–82.
81. Schafer D. Aging, longevity, and diet: historical remarks on calorie intake reduction. Gerontology 2005; 51: 126–30.
82. Shankar GM, Shaomin S, Mehta TH. Amyloid-β protein dimers isolated directly from Alzheimer’s brains impair synaptic plasticity and memory. Nature Medicine 2008; 14: 837–42.
83. Shin BK, Kang S, Kim DS, Park S. Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats. Exp Biol Med (Maywood) 2018; 243: 334–43.
84. Shivappa N, Wirth MD, Hurley TG, Hébert JR. Association between the dietary inflammatory index (DII) and telomere length and C-reactive protein from the National Health and Nutrition Examination Survey – 1999–2002. Mol Nutr Food Res 2017; 61: 10.
85. Siervo M, Arnold R, Wells JC, Tagliabue A, Colantuoni A, Albanese E, et al. Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis. Obes Rev 2011; 12: 968–83.
86. Sindi S, Kåreholt I, Eskelinen M, Hooshmand B, Lehtisalo J, Soininen H, et al. Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life. Nutrients 2018; 10: 1649.
87. Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, et al. Association of mediterranean diet with mild cognitive impairment and Alzheimer’s disease: a systematic review and meta-analysis. J Alzheimers Dis 2014; 39: 271–82.
88. Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R, Rastogi SS, et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single blind trial. Lancet 2002; 360: 1455–61.
89. Smith PJ, Blumenthal JA, Babyak MA, Craighead L, Welsh-Bohmer KA, Browndyke JN, et al. Effects of the dietary approaches to stop hypertension diet, exercise, and caloric
90. restriction on neurocognition in overweight adults with high blood pressure. Hypertension 2010; 55: 1331–38.
91. Smith PJ, Blumenthal JA. Dietary Factors and Cognitive Decline. J Prev Alzheimers Dis 2016; 3: 53–64.
92. Snowden SG, Ebshiana AA, Hye A, An Y, Pletnikova O, O’Brien R, et al. Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study. PLoS Med 2017; 14: e1002266.
93. Sofi F. The Mediterranean diet revisited: evidence of its effectiveness grows. Curr Opin Cardiol 2009; 24: 442–46.
94. Sofi F, Macchi C, Abbate R, Gensini GF, Casini A. Effectiveness of the Mediterranean diet: can it help delay or prevent Alzheimer’s disease? J Alzheimers Dis 2010; 20: 795–801.
95. Solfrizzi V, Panza F, Frisardi V, Seripa D, Logroscino G, Imbimbo BP, et al. Diet and Alzheimer’s disease risk factors or prevention: the current evidence Expert Rev Neurother 2011; 11: 677–708.
96. Solfrizzi V, Capurso C, D’Introno A. Lifestyle-related factors in predementia and dementia syndromes. Expert Rev Neurother 2008; 8: 133–58.
97. Soliman GA. Intermittent fasting and time-restricted eating role in dietary interventions and precision nutrition. Front Public Health 2022; 10: 1017254.
98. Swerdlow RH. Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer’s disease. Antioxid Redox Signal. 2012; 16: 1434–55.
99. Swindell WR. Dietary restriction in rats and mice: a meta-analysis and review of the evidence for genotype-dependent effects on lifespan. Ageing Res Rev 2012; 11: 254–70.
100. Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab 2018; 27: 1212–21.
101. To J, Shao ZY, Gandawidjaja M, Tabibi T, Grysman N, Grossberg GT. Comparison of the Impact of the Mediterranean Diet, Anti-Inflammatory Diet, Seventh-Day Adventist Diet, and Ketogenic Diet Relative to Cognition and Cognitive Decline. Curr Nutr Rep 2022; 11 (2): 161–71.
102. de la Torre JC. Alzheimer’s disease is incurable but preventable. J Alzheimers Dis 2010; 20: 861–70.
103. Wahla D, Coggera VC, Solon-Bieta SM, Waern RV, Gokarn R, Pulpitel T, et al. Nutritional strategies to optimise cognitive function in the aging brain. Ageing Research Reviews 2016; 31: 80–92.
104. Walsh S, Aisen PS. Inflammatory processes and Alzheimer’s disease. Expert Rev Neurother 2004; 4: 793–98.
105. Watanabe M, Tuccinardi D, Ernesti I, Basciani S, Mariani S, Genco A, et al. Scientific evidence underlying contraindications to the ketogenic diet: An update. Obes Rev 2020; 21 (10): e13053.
106. Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, He Q, et al. Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world’s longest-lived people and its potential impact on morbidity and life span. Ann N Y Acad Sci 2007; 1114: 434–55.
107. Willette AA, Coe CL, Birdsill AC, Bendlin BB, Colman RJ, Alexander AL, et al. Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques. Age (Dordr) 2013; 35: 2215–27.
108. Witte AV, Fobker M, Gellner R, Knecht S, Floel A. Caloric restriction improves memory in elderly humans. Proc Natl Acad Sci U S A 2009; 106: 1255–60.
109. Vafeiadou K, Vauzour D, Lee HY, Rodriguez-Mateos A, Williams RJ, Spencer JP.
110. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch Biochem Biophys 2009; 484: 100-9.
111. van den Brink AC, Brouwer-Brolsma EM, Berendsen AA. Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer’s Disease – A Review. Adv Nutr 2019; 10: 1040–65.
112. Vogt NM, Kerby RL, Dill-McFarland KA, Harding SJ, Merluzzi AP, Johnson SC, et al. Gut microbiome alterations in Alzheimer’s disease. Sci Rep 2017; 7: 13537.
113. Yoon G, Song J. Intermittent Fasting: a Promising Approach for Preventing Vascular Dementia. J Lipid Atheroscler 2019; 8: 1–7.
114. Yusufov M, Weyandt LL, Piryatinsky I. Alzheimer’s disease and diet: a systematic review. International Journal of Neuroscience 2017; 127: 161–75.
115. Xu W, Tan L, Wang HF, Jiang T, Tan MS, Tan L et al. Meta-analysis of modifiable risk factors for Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2015; 86: 1299–306.
116. Zaptan A, Akgün-Dar, Kapucu A, Dedeakayo˘gullari H, Batu S¸ Üzüm G, et al. Long term consequences on spatial learning-memory of low-calorie diet during adolescence in female rats; hippocampal and prefrontal cortex BDNF level, expression of NeuN and cell proliferation in the dentate gyrus. Brain Res 2015; 1618: 194–204.
117. Zhao J, Zhang X, Liu H, Brown MA, Qiao S. Dietary Protein and Gut Microbiota Composition and Function. Curr Protein Pept Sci 2019; 20: 145–154.

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