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ISSN: 1233-9687
Polish Journal of Pathology
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3/2015
vol. 66
 
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abstract:
Original paper

Omentin serum concentration and hepatic expression in chronic hepatitis C patients – together or apart?

Michał Kukla
,
Marek Waluga
,
Brygida Adamek
,
Marzena Zalewska-Ziob
,
Janusz Kasperczyk
,
Andrzej Gabriel
,
Rafał J. Bułdak
,
Barbara Sobala-Szczygieł
,
Lucjan Kępa
,
Katarzyna Ziora
,
Krystyna Żwirska-Korczala
,
Edward Surma
,
Tomasz Sawczyn
,
Marek Hartleb

Pol J Pathol 2015; 66 (3): 231-238
DOI: https://doi.org/10.5114/pjp.2015.54956
Online publish date: 2015/10/23
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Chronic hepatitis C (CHC) is accompanied by numerous metabolic disorders, partially associated with altered adipokine system regulation. Omentin (intelectin-1) is a novel adipokine known to play a pivotal role in metabolic regulation in CHC.

In a group of 63 CHC patients (29 men/34 women) infected with genotype 1b, aged 6.6 ±14.6 years, serum omentin levels and its gene expression in liver tissue were examined and their association with metabolic and histopathological features was assessed.

Serum omentin levels were significantly higher in CHC patients compared to controls (p < 0.001), regardless of sex, body mass index (BMI), insulin sensitivity and lipid concentrations. There was no correlation between serum omentin and omentin hepatic expression. Neither parameter was associated with any histological features.

Serum omentin in non-obese CHC patients seems not to be related to metabolic disorders or liver pathology. Omentin hepatic expression shows no relationship with either serum omentin levels or histopathological features. This suggests different mechanisms regulating circulating omentin concentration and omentin hepatic expression in CHC.
keywords:

omentin, adipokine, chronic hepatitis C, fibrosis, insulin resistance, steatosis, liver
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