Origin and pathological characteristics of Klatskin tumor: a case report and literature review

Ljiljana Somer; Bojana Andrejić; Pavle Milošević

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2012
vol. 63

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abstract:

Origin and pathological characteristics of Klatskin tumor: a case report and literature review

Ljiljana Somer

,

Bojana Andrejić

,

Pavle Milošević

Pol J Pathol 2012; 1: 65-70

Online publish date: 2012/04/24

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Hilar cholangiocarcinomas involving the bifurcation of the hepatic duct are called Klatskin tumors. A resected specimen of the hilar hepatic region with Klatskin tumor was analyzed. The lining epithelium of major biliary ducts was regular, while the majority of epithelial cells lining the excretory ducts of peribiliary glands (PBGs) exhibited malignant features. The connective tissue surrounding the PBGs was infiltrated by mucinous malignant epithelial cells, sometimes in a signet-ring cell form, with perineural invasion. The tumor epithelial cells showed distinct CK 7 and CA 19-9 positivity. The described cholangiocarcinoma was classified as the Bismuth-Corlette type IIIb and originated from the excretory ducts and acinar cells of PBGs.

keywords:

Origin and pathological characteristics of Klatskin tumor: a case report and literature review

Ljiljana Somer , Bojana Andrejić , Pavle Milošević

cholangiocarcinoma, Klatskin tumor, biliary tract, cytokeratin 7, CA 19-9

Ljiljana Somer

,

Bojana Andrejić

,

Pavle Milošević