Original paper<br>Association between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women

Magdalena M. Michalska; Dariusz Samulak; Jan Bieńkiewicz; Hanna Romanowicz; Beata Smolarz

doi:10.5114/pjp.2015.51155

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2015
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abstract:

Original paper
Association between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women

Magdalena M. Michalska

,

Dariusz Samulak

,

Jan Bieńkiewicz

,

Hanna Romanowicz

,

Beata Smolarz

Pol J Pathol 2015; 66 (1): 67-71

DOI: https://doi.org/10.5114/pjp.2015.51155

Online publish date: 2015/05/04

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Aim of the study: The XRCC2 gene plays a crucial role in double-strand DNA break repair by homologous recombination. Current literature provides clear evidence that XRCC2 polymorphisms may be associated with the development of certain types of cancer; however, still little is known about their association with endometrial cancer (EC).

Material and methods: The single nucleotide polymorphism (SNP) -41657C/T (rs718282) of the XRCC2 gene was investigated by PCR-RFLP in 304 patients with EC and in 200 age- and sex-matched non-cancer controls.

Results: The analysis revealed a relationship between XRCC2 -41657C/T polymorphism and the incidence of EC. Endometrial cancer patients showed overrepresentation of the T allele of the SNP. The T/T homozygous variant increased the cancer risk. There were no significant differences between the distribution of XRCC2 -41657C/T genotypes in the subgroups according to histological grade.

Conclusions: This is the first study that links the SNP -41657C/T (rs718282) of the XRCC2 gene with EC in Polish women. The results support the hypothesis that this polymorphism may be positively correlated with the incidence of EC.

keywords:

Original paperAssociation between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women

Magdalena M. Michalska , Dariusz Samulak , Jan Bieńkiewicz , Hanna Romanowicz , Beata Smolarz

endometrial cancer, XRCC2 gene, genetic polymorphism

Original paper
Association between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women

Magdalena M. Michalska

,

Dariusz Samulak

,

Jan Bieńkiewicz

,

Hanna Romanowicz

,

Beata Smolarz