Original paper<br>Comparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens

Sławomir Poletajew; Łukasz Fus; Maciej Walędziak; Paweł Pomada; Joanna Ciechańska; Aleksander Wasiutyński; Piotr Radziszewski; Barbara Górnicka

doi:10.5114/pjp.2014.48192

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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abstract:

Original paper
Comparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens

Sławomir Poletajew

,

Łukasz Fus

,

Maciej Walędziak

,

Paweł Pomada

,

Joanna Ciechańska

,

Aleksander Wasiutyński

,

Piotr Radziszewski

,

Barbara Górnicka

Pol J Pathol 2014; 65 (4): 305-312

DOI: https://doi.org/10.5114/pjp.2014.48192

Online publish date: 2015/02/02

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AMA

Poletajew S, Fus Ł, Walędziak M, et al. Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens. Polish Journal of Pathology. 2014;65(4):305-312. doi:10.5114/pjp.2014.48192.

APA

Poletajew, S., Fus, Ł., Walędziak, M., Pomada, P., Ciechańska, J.,  & Wasiutyński, A. et al. (2014). Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens. Polish Journal of Pathology, 65(4), 305-312. https://doi.org/10.5114/pjp.2014.48192

Chicago

Poletajew, Sławomir, Łukasz Fus, Maciej Walędziak, Paweł Pomada, Joanna Ciechańska, Aleksander Wasiutyński,  and Piotr Radziszewski et al. 2014. "Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens". Polish Journal of Pathology 65 (4): 305-312. doi:10.5114/pjp.2014.48192.

Harvard

Poletajew, S., Fus, Ł., Walędziak, M., Pomada, P., Ciechańska, J., Wasiutyński, A., Radziszewski, P.,  and Górnicka, B. (2014). Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens. Polish Journal of Pathology, 65(4), pp.305-312. https://doi.org/10.5114/pjp.2014.48192

MLA

Poletajew, Sławomir et al. "Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens." Polish Journal of Pathology, vol. 65, no. 4, 2014, pp. 305-312. doi:10.5114/pjp.2014.48192.

Vancouver

Poletajew S, Fus Ł, Walędziak M, Pomada P, Ciechańska J, Wasiutyński A et al. Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens. Polish Journal of Pathology. 2014;65(4):305-312. doi:10.5114/pjp.2014.48192.

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Staging and grading of bladder cancer have a substantial impact on patients’ prognosis. However, due to the relatively low quality and quantity of specimens from transurethral resection (TUR), initial histopathological examination may not be fully reliable.

The aim of this study was to assess the repeatability of staging and grading in post-TUR and post-radical cystectomy (RC) specimens.

Staging and grading in TUR and RC specimens were compared in a group of 181 consecutive patients. All microscopic examinations were performed by dedicated uropathologists. Median time from TUR to RC was 45 days. Additionally, an attempt to identify potential clinical variables influencing the risk of discrepancies was made.

In post-RC specimens, the disease was down-staged in 13.8% and up-staged in 54.6% of patients (K = –0.03, p < 0.02). Muscle-invasive bladder cancer was diagnosed in 67.6% of patients initially staged as T1. Cancer was down-graded in 10.3% and up-graded in 17.9% of patients (K = 0.44, p < 0.02). Early onset of disease, female sex and time interval from transurethral resection of bladder tumor (TURBT) to RC had no effect on incidence of discrepancies.

Pathological post-TUR examination is not predictive for the final stage of cancer. The incidence of under- or overgrading of bladder cancer is significant, and efforts should be made to reduce it.

keywords:

Original paperComparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens

Sławomir Poletajew , Łukasz Fus , Maciej Walędziak , Paweł Pomada , Joanna Ciechańska , Aleksander Wasiutyński , Piotr Radziszewski , Barbara Górnicka

bladder cancer, cancer staging, TNM staging, tumor grading, histopathology

Original paper
Comparison of pathological staging and grading of urothelial bladder carcinoma in post-transurethral resection and post-radical cystectomy specimens

Sławomir Poletajew

,

Łukasz Fus

,

Maciej Walędziak

,

Paweł Pomada

,

Joanna Ciechańska

,

Aleksander Wasiutyński

,

Piotr Radziszewski

,

Barbara Górnicka