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ISSN: 1233-9687
Polish Journal of Pathology
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2/2015
vol. 66
 
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abstract:

Original paper
Multifocal/multicentric breast carcinomas showing intertumoural heterogeneity: a comparison of histological tumour type and Nottingham histological grade of primary tumour and lymph node metastasis

Monica Boros
,
Cristian Podoleanu
,
Rares Georgescu
,
Cosmin Moldovan
,
Calin Molnar
,
Simona Stolnicu

Pol J Pathol 2015; 66 (2): 125-132
DOI: https://doi.org/10.5114/pjp.2015.53008
Online publish date: 2015/07/28
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Our study aimed to compare the histological tumour type and Nottingham histological grade of invasive tumour foci in multifocal/multicentric breast carcinomas with those in corresponding axillary lymph node (LN) metastases.

We reassessed slides from consecutive multiple breast carcinomas surgically treated with axillary LN dissection (2007-2012).

155 (19.23%) of 806 cases had multiple breast cancer, of which 115 (74.19%) cases had identical morphology. Of these, 85 (73.91%) cases had axillary LN metastases morphologically identical to the originating breast tumours. 32 of the 40 (80%) cases with different morphology had axillary LN metastases; in most heterogeneous cases with differences in grade (87.5%), the grade of metastases was identical to the grade of the tumour foci with the highest histological grade, and in 33.33% of cases the grade in LN was concordant with the grade of smaller foci. Among the 18 cases heterogeneous in histological type with axillary metastases, 33.33% presented heterogeneous histological types in LN, and 22.22% of them were only concordant with the histological type of the smaller tumour foci.

The morphological aspects of axillary LN metastases correspond to the highest histological grade and/or histological tumour type with unfavourable prognosis, which does not necessarily appear in the largest tumour focus.
keywords:

heterogeneity, lymph node metastases, multiple breast carcinoma
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