Original paper<br>Role of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy

Ahmet Arif Yalcin; Mustafa Topuz; Ismail Biyik; Ibrahim Faruk Akturk; Omer Celik; Nilgun Isiksacan; Burce Yalcın; Ali Birant; Fatih Uzun

doi:10.5114/pwki.2014.46765

eISSN: 1897-4295
ISSN: 1734-9338

Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej

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Original paper
Role of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy

Ahmet Arif Yalcin

,

Mustafa Topuz

,

Ismail Biyik

,

Ibrahim Faruk Akturk

,

Omer Celik

,

Nilgun Isiksacan

,

Burce Yalcın

,

Ali Birant

,

Fatih Uzun

Postep Kardiol Inter 2014; 10, 4 (38): 242–249

DOI: https://doi.org/10.5114/pwki.2014.46765

Online publish date: 2014/11/17

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AMA

Yalcin A, Topuz M, Biyik I, et al. Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2014;10(4):242-249. doi:10.5114/pwki.2014.46765.

APA

Yalcin, A., Topuz, M., Biyik, I., Akturk, I., Celik, O.,  & Isiksacan, N. et al. (2014). Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 10(4), 242-249. https://doi.org/10.5114/pwki.2014.46765

Chicago

Yalcin, Ahmet Arif, Mustafa Topuz, Ismail Biyik, Ibrahim Faruk Akturk, Omer Celik, Nilgun Isiksacan,  and Burce Yalcın et al. 2014. "Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy". Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej 10 (4): 242-249. doi:10.5114/pwki.2014.46765.

Harvard

Yalcin, A., Topuz, M., Biyik, I., Akturk, I., Celik, O., Isiksacan, N., Yalcın, B., Birant, A.,  and Uzun, F. (2014). Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, 10(4), pp.242-249. https://doi.org/10.5114/pwki.2014.46765

MLA

Yalcin, Ahmet Arif et al. "Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy." Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej, vol. 10, no. 4, 2014, pp. 242-249. doi:10.5114/pwki.2014.46765.

Vancouver

Yalcin A, Topuz M, Biyik I, Akturk I, Celik O, Isiksacan N et al. Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy. Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej. 2014;10(4):242-249. doi:10.5114/pwki.2014.46765.

Introduction: Accumulating evidence now indicates that insulin-like growth factors (IGF) and their regulatory proteins are growth promoters for arterial cells and mediators of cardiovascular diseases.

Aim: We hypothetised that IGF-1 levels could play a role in the development of stent thrombosis (ST), and aimed to investigate the associations between stent thrombosis under effective dual antiplatelet therapy and IGF-1 levels and other related factors such as disease severity and LV ejection fraction in patients undergoing coronary stent placement.

Material and methods: A total of 128 patients undergoing coronary stent implantation were included in the analysis. Seventy-seven patients experiencing ST in the first year after stent implantation were defined as the ST group. Fifty-one patients without ST at least 1 year after stent implantation were defined as the no-thrombosis (NT) group. The IGF-1 levels, Gensini scores, and other related factors were measured.

Results: The IGF-1 levels were significantly higher in the stent thrombosis group than in the no-thrombosis group (122.22 ±50.61 ng/ml vs. 99.52 ±46.81 ng/ml, respectively, p < 0.039). The left ventricle ejection fraction (LVEF) values were significantly lower (44.13 ±9.25% vs. 55.81 ±8.77%, p < 0.0001) and Gensini scores were significantly higher (63.74 ±26.54 vs. 48.87 ±23.7, p < 0.004) in the ST group than in the NT group, respectively. In the linear regression analysis, IGF-1, Gensini score, LVEF, total cholesterol, and triglycerides were found to be independent risk factors for ST.

Conclusions: This study revealed that the plasma IGF-1 levels, disease severity, were significantly higher and LVEF was lower in patients with ST. High IGF-1 levels may identify patients who are at increased risk for ST. Future trials are necessary to confirm these results.

keywords:

Original paperRole of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy

Ahmet Arif Yalcin , Mustafa Topuz , Ismail Biyik , Ibrahim Faruk Akturk , Omer Celik , Nilgun Isiksacan , Burce Yalcın , Ali Birant , Fatih Uzun

insulin like growth factor 1, stent thrombosis, Gensini score, left ventricle ejection fraction

Original paper
Role of insulin-like growth factor 1 in stent thrombosis under effective dual antiplatelet therapy

Ahmet Arif Yalcin

,

Mustafa Topuz

,

Ismail Biyik

,

Ibrahim Faruk Akturk

,

Omer Celik

,

Nilgun Isiksacan

,

Burce Yalcın

,

Ali Birant

,

Fatih Uzun