Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis

Ping Wu; Xizhou Li; Yangmei Wu; Wei Hu; Yang Wang; Li Gao; Zhongzhong Chen; Weiqiang Zheng

doi:10.5114/wo.2014.47037

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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6/2014
vol. 18

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abstract:

Original paper

Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis

Ping Wu

,

Xizhou Li

,

Yangmei Wu

,

Wei Hu

,

Yang Wang

,

Li Gao

,

Zhongzhong Chen

,

Weiqiang Zheng

Contemp Oncol (Pozn) 2014; 18 (6): 391–395

DOI: https://doi.org/10.5114/wo.2014.47037

Online publish date: 2014/12/03

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Aim of the study: Increased Raf-1 expression has been associated with an aggressive behaviour in some carcinomas such as pulmonary carcinoma and renal carcinoma. However, its role in breast cancer, especially in basal-like carcinoma of the breast (BLBC), has not been defined.

Material and methods: The current study attempted to investigate the expression pattern of Raf-1 protein in BLBC, in relation to the biological behaviour and prognosis of the carcinoma. Expression of Raf-1 was detected by immunohistochemistry in carcinoma specimens from 74 cases of BLBC, and associations between their expression and the clinicopathological characteristics were statistically assessed.

Results: The patients’ age, tumour size, BRCA1, and p53 protein expression was not significantly different between the Raf-1-positive and Raf-1-negative expression groups (p > 0.05). The proportion of histological grade 3 tumours was not significantly higher in the Raf-1 positive group than that of grade 2 tumours (p > 0.05). However, positive cytoplasmic Raf-1 expression was positively correlated to Ki-67 expression (p < 0.05). Also, increased Raf-1 protein was found to exert an unfavourable impact on patients’ axillary lymph node metastasis and overall survival (p < 0.05).

Conclusions: The study implies that positive Raf-1 expression in BLBC is associated with a more aggressive phenotype and could be considered as a new prognostic biomarker for poor survival in BLBC patients.

keywords:

Overexpression of Raf-1 in basal-like carcinoma of the breast: correlation with clinicopathology and prognosis

Ping Wu , Xizhou Li , Yangmei Wu , Wei Hu , Yang Wang , Li Gao , Zhongzhong Chen , Weiqiang Zheng

Raf-1, basal-like breast carcinoma, aggressive phenotype

Ping Wu

,

Xizhou Li

,

Yangmei Wu

,

Wei Hu

,

Yang Wang

,

Li Gao

,

Zhongzhong Chen

,

Weiqiang Zheng