|
Current issue
Archive
Videos
Articles in press
About the journal
Supplements
Editorial board
Reviewers
Abstracting and indexing
Subscription
Contact
Instructions for authors
Publication charge
Ethical standards and procedures
Editorial System
Submit your Manuscript
|
4/2013
vol. 115 abstract:
Review paper
Oxidative stress in the pathogenesis of keratoconus
Katarzyna A. Wójcik
1
,
Janusz Błasiak
1
,
Anna K. Kurowska
2
,
Jerzy Szaflik
2, 3
,
Jacek P. Szaflik
2, 3
Klinika Oczna 2013, 115 (4): 311-316
Online publish date: 2013/12/22
View
full text
Get citation
ENW EndNote
BIB JabRef, Mendeley
RIS Papers, Reference Manager, RefWorks, Zotero
AMA
APA
Chicago
Harvard
MLA
Vancouver
Keratoconus is a non-inflammatory corneal disease, which involves changes of the corneal shape, due to thinning of the corneal stroma. The pathogenesis of this disease has remained unclear, but results of many studies indicate that keratoconus is a multifactorial disease. It is hypothesized, that this disorder is associated with both genetic and environmental factors. An increase in toxic products of lipid peroxidation and nitric oxide pathways, as well as decreased levels of some enzymatic and non-enzymatic antioxidants seen in keratoconus, suggest an important role of oxidative stress in the pathogenesis of this disease. It seems that the interactions of reactive oxygen and nitric species with cellular components including nucleic acids, membranę lipids and proteins, may activate a series of events leading to keratoconus. The excess amount of reactive oxygen and nitric species may induce mitochondrial DNA (mtDNA) damage, the extent of which increases in corneas with keratoconus. This damage may disturb the mitochondrial process of oxidative phosphorylation, resulting in further increase in formation of reactive oxygen and nitric species. Furthermore, some elements of oxidative stress can be involved in the activation of certain proteinases and release of lysosomal enzymes, which may be important for corneal thinning in keratoconus.
keywords:
keratoconus, oxidative stress, antioxidants, free radicals |
|
POLSKI
