PREVENTION OF ADHESIVE FORMATION UNDER EXPERIMENTAL CONDITIONS

Background
Prevention of adhesions remains an urgent problem of abdominal surgery, despite the significant amount of research in this area. In the prevention of adhesions there are four areas: reduction of peritoneal injury; reduction of the inflammatory reaction in the area of ​​operation; the effect of remedial drugs on the balance of formation and destruction of fibrin; delimitation of damaged serous membranes by the formation of protective films on the mesothelium.

Material and methods
84 laboratory mature white male rats, which were divided into 8 groups, were studied. The adhesion process was simulated with some groups using an anti-adhesive based on hyaluronic acid. On the 4th, 10th, and 30th day after the beginning of the experiment, the experimental animals were euthanized, the abdominal cavity was opened, and the visceral and parietal peritoneum and adhesions were examined through standard macroscopic and microscopic methods.

Results
During the correction of the simulated pathological process by Defensal, the number of adhesions decreased by 42.8%. The thickness of the adhesions under the influence of the above drug decreased by 3.5 times compared to the control group.

Conclusions
Studies and results show that a barrier drug such as Defensal has a positive effect on the course of experimental adhesive disease. During the use of this drug, in the abdominal cavity, the number of adhesions significantly decreased, and the vast majority were filamentous, loose, easily separated, did not deform the lumen structure and almost did not change the digestive tract.