Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis

Agnieszka Owczarczyk-Saczonek; Dorota Purzycka-Bohdan; Bogusław Nedoszytko; Adam Reich; Aneta Szczerkowska-Dobosz; Joanna Bartosińska; Aleksandra Batycka-Baran; Rafał Czajkowski; Iwona Dobrucki; Lawrence Dobrucki; Magdalena Górecka-Sokołowska; Anna Janaszak-Jasiecka; Leszek Kalinowski; Dorota Krasowska; Adrianna Radulska; Edyta Reszka; Dominik Samotij; Andrzej Słominski; Radomir Słominski; Marta Sobalska-Kwapis; Marta Stawczyk-Macieja; Dominik Strapagiel; Justyna Szczęch; Michał Żmijewski; Roman Nowicki

doi:10.5114/ada.2020.98284

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis in psoriasis

Agnieszka Owczarczyk-Saczonek

¹

,

Dorota Purzycka-Bohdan

²

,

Bogusław Nedoszytko

²

,

Adam Reich

³

,

Aneta Szczerkowska-Dobosz

²

,

Joanna Bartosińska

⁴

,

Aleksandra Batycka-Baran

⁵

,

Rafał Czajkowski

⁶

,

Iwona T. Dobrucki

⁷

,

Lawrence W. Dobrucki

^{7, 8, 9, 10}

,

Magdalena Górecka-Sokołowska

⁵

,

Anna Janaszak-Jasiecka

⁹

,

Leszek Kalinowski

^{9, 11, 12}

,

Dorota Krasowska

⁴

,

Adrianna Radulska

¹³

,

Edyta Reszka

¹¹

,

Dominik Samotij

³

,

Andrzej Słominski

¹⁴

,

Radomir Słominski

¹⁵

,

Marta Sobalska-Kwapis

¹⁶

,

Marta Stawczyk-Macieja

²

,

Dominik Strapagiel

¹⁶

,

Justyna Szczęch

³

,

Michał Żmijewski

¹⁷

,

Roman J. Nowicki

²

Chair and Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland
Chair and Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
Department of Dermatology, University of Rzeszow, Rzeszow, Poland
Chair and Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland
Chair and Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
Chair and Department of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland
Beckman Institute for Advanced Science and Technology, Urbana, IL, USA
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland
Biobanking and Biomolecular Resources Research Infrastructure Poland (BBMRI.PL), Gdansk, Poland
Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland
Gdansk University of Technology, Gdansk, Poland
Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
Department of Dermatology, University of Alabama at Birmingham, Birmingham, USA
Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA
Biobank Laboratory, University of Lodz, Lodz, Poland
Department of Histology, Medical University of Gdansk, Gdansk, Poland

Adv Dermatol Allergol 2020; XXXVII (4): 452–467

DOI: https://doi.org/10.5114/ada.2020.98284

Online publish date: 2020/09/02

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AMA

Owczarczyk-Saczonek A, Purzycka-Bohdan D, Nedoszytko B, et al. Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(4):452-467. doi:10.5114/ada.2020.98284.

APA

Owczarczyk-Saczonek, A., Purzycka-Bohdan, D., Nedoszytko, B., Reich, A., Szczerkowska-Dobosz, A.,  & Bartosińska, J. et al. (2020). Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(4), 452-467. https://doi.org/10.5114/ada.2020.98284

Chicago

Owczarczyk-Saczonek, Agnieszka, Dorota Purzycka-Bohdan, Bogusław Nedoszytko, Adam Reich, Aneta Szczerkowska-Dobosz, Joanna Bartosińska,  and Aleksandra Batycka-Baran et al. 2020. "Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 37 (4): 452-467. doi:10.5114/ada.2020.98284.

Harvard

Owczarczyk-Saczonek, A., Purzycka-Bohdan, D., Nedoszytko, B., Reich, A., Szczerkowska-Dobosz, A., Bartosińska, J., Batycka-Baran, A., Czajkowski, R., Dobrucki, I., Dobrucki, L., Górecka-Sokołowska, M., Janaszak-Jasiecka, A., Kalinowski, L., Krasowska, D., Radulska, A., Reszka, E., Samotij, D., Słominski, A., Słominski, R., Sobalska-Kwapis, M., Stawczyk-Macieja, M., Strapagiel, D., Szczęch, J., Żmijewski, M.,  and Nowicki, R. (2020). Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(4), pp.452-467. https://doi.org/10.5114/ada.2020.98284

MLA

Owczarczyk-Saczonek, Agnieszka et al. "Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 37, no. 4, 2020, pp. 452-467. doi:10.5114/ada.2020.98284.

Vancouver

Owczarczyk-Saczonek A, Purzycka-Bohdan D, Nedoszytko B, Reich A, Szczerkowska-Dobosz A, Bartosińska J et al. Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
in psoriasis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(4):452-467. doi:10.5114/ada.2020.98284.

Psoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and the production of inflammatory mediators involved in the development of both psoriasis and metabolic disorders. However, in psoriasis the activation of the Th17/IL-17 and the abnormalities in the Th17/Treg balance axis are observed, but this pathomechanism does not fully explain the frequent occurrence of metabolic disorders. Therefore, there is a need to look for better biomarkers in the diagnosis, prognosis and monitoring of concomitant disorders and therapeutic effects in psoriasis. In addition, the education on the use of a proper diet as a prophylaxis for the development of the above disorders is an important element of holistic care for a patient with psoriasis. Diet may affect gene expression due to epigenetic modification which encompasses interactions of environment, nutrition and diseases. Patients with psoriasis should be advised to adopt proper diet and dietician support.

keywords:

Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis in psoriasis

psoriasis, inflammation, metabolic syndrome, metabolomics, proteomic nutrigenomics