Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis

Aneta Szczerkowska-Dobosz; Dorota Krasowska; Joanna Bartosińska; Marta Stawczyk-Macieja; Aleksandra Walczak; Agnieszka Owczarczyk-Saczonek; Adam Reich; Aleksandra Batycka-Baran; Rafał Czajkowski; Iwona Dobrucki; Lawrence Dobrucki; Magdalena Górecka-Sokołowska; Anna Janaszak-Jasiecka; Leszek Kalinowski; Roman Nowicki; Agata Płoska; Dorota Purzycka-Bohdan; Adrianna Radulska; Edyta Reszka; Dominik Samotij; Anna Siekierzycka; Andrzej T. Slominski; Radomir M. Slominski; Marta Sobalska-Kwapis; Dominik Strapagiel; Justyna Szczęch; Michał Żmijewski; Bogusław Nedoszytko

doi:10.5114/ada.2020.100478

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis

Aneta Szczerkowska-Dobosz

¹

,

Dorota Krasowska

²

,

Joanna Bartosińska

²

,

Marta Stawczyk-Macieja

¹

,

Aleksandra Walczak

²

,

Agnieszka Owczarczyk-Saczonek

³

,

Adam Reich

⁴

,

Aleksandra Batycka-Baran

⁵

,

Rafał Czajkowski

⁶

,

Iwona T. Dobrucki

⁷

,

Lawrence W. Dobrucki

^{7, 8, 9}

,

Magdalena Górecka-Sokołowska

¹⁰

,

Anna Janaszak-Jasiecka

^{8, 9}

,

Leszek Kalinowski

^{7, 8, 9}

,

Roman J. Nowicki

¹

,

Agata Płoska

^{8, 9}

,

Dorota Purzycka-Bohdan

¹

,

Adrianna Radulska

^{8, 9}

,

Edyta Reszka

¹¹

,

Dominik Samotij

⁴

,

Anna Siekierzycka

^{8, 9}

,

Andrzej T. Slominski

^{12, 13, 14}

,

Radomir M. Slominski

¹⁵

,

Marta Sobalska-Kwapis

¹⁶

,

Dominik Strapagiel

¹⁰

,

Justyna Szczęch

⁴

,

Michał Żmijewski

¹⁷

,

Bogusław Nedoszytko

¹

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland
Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland
Department of Dermatology, University of Rzeszow, Rzeszow, Poland
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland
Department of Dermatology, Sexually Transmitted Disorders and Immunodermatology, Jurasz University Hospital No. 1, Bydgoszcz, Poland
Beckman Institute for Advanced Science and Technology, Urbana, IL, USA
Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA
Department of Medical Laboratory Diagnostics, Medical University of Gdansk, Gdansk, Poland
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI.PL), Gdansk, Poland
Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational Medicine, Lodz, Poland
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL, USA
Pathology and Laboratory Medicine, VA Medical Center, Birmingham, AL, USA
Department of Medicine and Microbiology, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA
Biobank Lab, Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland
Department of Histology, Medical University of Gdansk, Gdansk, Poland

Adv Dermatol Allergol 2020; XXXVII (5): 625-634

DOI: https://doi.org/10.5114/ada.2020.100478

Online publish date: 2020/11/07

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AMA

Szczerkowska-Dobosz A, Krasowska D, Bartosińska J, et al. Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(5):625-634. doi:10.5114/ada.2020.100478.

APA

Szczerkowska-Dobosz, A., Krasowska, D., Bartosińska, J., Stawczyk-Macieja, M., Walczak, A.,  & Owczarczyk-Saczonek, A. et al. (2020). Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(5), 625-634. https://doi.org/10.5114/ada.2020.100478

Chicago

Szczerkowska-Dobosz, Aneta, Dorota Krasowska, Joanna Bartosińska, Marta Stawczyk-Macieja, Aleksandra Walczak, Agnieszka Owczarczyk-Saczonek,  and Adam Reich et al. 2020. "Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 37 (5): 625-634. doi:10.5114/ada.2020.100478.

Harvard

Szczerkowska-Dobosz, A., Krasowska, D., Bartosińska, J., Stawczyk-Macieja, M., Walczak, A., Owczarczyk-Saczonek, A., Reich, A., Batycka-Baran, A., Czajkowski, R., Dobrucki, I., Dobrucki, L., Górecka-Sokołowska, M., Janaszak-Jasiecka, A., Kalinowski, L., Nowicki, R., Płoska, A., Purzycka-Bohdan, D., Radulska, A., Reszka, E., Samotij, D., Siekierzycka, A., Slominski, A., Slominski, R., Sobalska-Kwapis, M., Strapagiel, D., Szczęch, J., Żmijewski, M.,  and Nedoszytko, B. (2020). Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 37(5), pp.625-634. https://doi.org/10.5114/ada.2020.100478

MLA

Szczerkowska-Dobosz, Aneta et al. "Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 37, no. 5, 2020, pp. 625-634. doi:10.5114/ada.2020.100478.

Vancouver

Szczerkowska-Dobosz A, Krasowska D, Bartosińska J, Stawczyk-Macieja M, Walczak A, Owczarczyk-Saczonek A et al. Pathogenesis of psoriasis in the “omic” era. Part IV.
Epidemiology, genetics, immunopathogenesis, clinical
manifestation and treatment of psoriatic arthritis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2020;37(5):625-634. doi:10.5114/ada.2020.100478.

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis as well as a complex pathogenesis. Genetic and environmental factors trigger the development of the immune-mediated auto-inflammatory response in different sites: skin, bone marrow, entheses and synovial tissues. Studies of the last two decades have changed the view of PsA from a mild, non-progressive arthritis to an inflammatory systemic disease with serious health consequences, not only associated with joint dysfunction, but also with an increased risk of cardiovascular disease and socioeconomic consequences with significantly reduced quality of life. The joint damage starts early in the course of the disease, thus early recognition and treatment with modern biological treatments, which may modify the natural history and slow down progression of this debilitating disease, is essential for the patient long-term outcome.

keywords:

Pathogenesis of psoriasis in the “omic” era. Part IV. Epidemiology, genetics, immunopathogenesis, clinical manifestation and treatment of psoriatic arthritis

psoriatic arthritis, genetics, immunopathogenesis, classification, treatment