Pathomechanism of insulin resistance in chronic hepatitis C

Michał Kukla; Tomasz Sawczyn; Krystyna Żwirska-Korczala; Mirosław Jarosz

doi:10.5114/pg.2011.25376

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

5/2011
vol. 6

Send email

Copy url:

abstract:

Review paper

Pathomechanism of insulin resistance in chronic hepatitis C

Michał Kukla

,

Tomasz Sawczyn

,

Krystyna Żwirska-Korczala

,

Mirosław Jarosz

Przegląd Gastroenterologiczny 2011; 6 (5): 284–289

DOI: https://doi.org/10.5114/pg.2011.25376

Online publish date: 2011/11/11

View full text Get citation

PlumX metrics:

Chronic hepatitis C (CHC) should be considered not only as viral but also as a metabolic disease. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus, hepatic steatosis, lipid metabolism abnormalities and probably atherosclerosis are the main metabolic manifestations of CHC. The development of IR in CHC seems to be complex, resulting from an ongoing inflammatory process, up-regulation of pro-inflammatory cytokines, fibrosis progression and direct influence of the virus on the insulin signalling pathway. Insulin resistance promotes hepatic steatosis and is associated with fibrosis progression, resistance to antiviral therapy and development of hepatocellular carcinoma. Therefore, understanding the pathogenesis of this phenomenon may by essential to obtain higher efficacy of antiviral therapy and would be helpful in prevention of metabolic disturbances and complications in the course of CHC.

keywords:

Pathomechanism of insulin resistance in chronic hepatitis C

Michał Kukla , Tomasz Sawczyn , Krystyna Żwirska-Korczala , Mirosław Jarosz

insulin resistance, chronic hepatitis C, adipokines, fibrosis, liver

Michał Kukla

,

Tomasz Sawczyn

,

Krystyna Żwirska-Korczala

,

Mirosław Jarosz